R
Ralf R. Schumann
Researcher at Charité
Publications - 97
Citations - 7306
Ralf R. Schumann is an academic researcher from Charité. The author has contributed to research in topics: Innate immune system & Single-nucleotide polymorphism. The author has an hindex of 40, co-authored 95 publications receiving 6833 citations. Previous affiliations of Ralf R. Schumann include Humboldt State University.
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Journal ArticleDOI
Endotoxin and immune activation in chronic heart failure: a prospective cohort study.
Josef Niebauer,Hans-Dieter Volk,Michael Kemp,Martin Dominguez,Ralf R. Schumann,Mathias Rauchhaus,Philip A. Poole-Wilson,Andrew J.S. Coats,Stefan D. Anker,Stefan D. Anker +9 more
TL;DR: Raised concentrations of endotoxin and cytokines are found in patients with chronic heart failure during acute oedematous exacerbation and the preliminary findings suggest that endotoxin may trigger immune activation in patientsWith chronic heart fail, intensified diuretic treatment can normalise endotoxin concentrations.
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Toll-like receptor (TLR) polymorphisms in African children: Common TLR-4 variants predispose to severe malaria
Frank P. Mockenhaupt,Jakob P. Cramer,Jakob P. Cramer,Lutz Hamann,Miriam Stegemann,Jana Eckert,Na Ri Oh,Rowland N. Otchwemah,Ekkehart Dietz,Stephan Ehrhardt,Stephan Ehrhardt,Nicolas W. J. Schröder,Nicolas W. J. Schröder,Ulrich Bienzle,Ralf R. Schumann +14 more
TL;DR: TLR4-mediated responses to malaria in vivo and TLR-4 polymorphisms to be associated with disease manifestation are suggested, however some gray areas also suggest the scope for further improvements.
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Nucleotide-binding oligomerization domain proteins are innate immune receptors for internalized Streptococcus pneumoniae.
Bastian Opitz,Anja Püschel,Bernd Schmeck,Andreas C. Hocke,Simone Rosseau,Sven Hammerschmidt,Ralf R. Schumann,Norbert Suttorp,Stefan Hippenstiel +8 more
TL;DR: It is demonstrated that in C57BL/6 mouse lung tissue in vivo as well as in the bronchial epithelial cell line BEAS-2B, Nod1 and Nod2 mRNA expressions were up-regulated after pneumococcal infection, suggesting that Nod proteins contribute to innate immune recognition of S. pneumoniae.
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LPS-binding protein protects mice from septic shock caused by LPS or gram-negative bacteria.
Norbert Lamping,R. Dettmer,Nicolas W.J. Schröder,D. Pfeil,W. Hallatschek,Reinhard Burger,Ralf R. Schumann +6 more
TL;DR: It is concluded that acute phase LBP has a protective effect against LPS and bacterial infection and may represent a physiologic defense mechanism against infection.
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Gram-Negative Bacteria Aggravate Murine Small Intestinal Th1-Type Immunopathology following Oral Infection with Toxoplasma gondii
Markus M. Heimesaat,Stefan Bereswill,André Fischer,David Fuchs,Daniela Struck,Julia Niebergall,Hannah-Katharina Jahn,Ildiko R. Dunay,Annette Moter,Dorothee Maria Gescher,Ralf R. Schumann,Ulf B. Göbel,Oliver Liesenfeld +12 more
TL;DR: Gram-negative bacteria, i.e., E. coli, aggravate pathogen-induced intestinal Th1-type immunopathology and may prove useful to study bacteria-host interactions in small intestinal inflammation and to test novel therapies based on modulation of gut flora.