R
Ralph Alderson
Researcher at Laboratory of Molecular Biology
Publications - 23
Citations - 550
Ralph Alderson is an academic researcher from Laboratory of Molecular Biology. The author has contributed to research in topics: Cancer & Immunotherapy. The author has an hindex of 7, co-authored 23 publications receiving 467 citations.
Papers
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Journal ArticleDOI
Development of an Fc-Enhanced Anti–B7-H3 Monoclonal Antibody with Potent Antitumor Activity
Deryk T. Loo,Ralph Alderson,Francine Chen,Ling Huang,Wenjun Zhang,Sergey Gorlatov,Steve Burke,Valentina Ciccarone,Hua Li,Yinhua Yang,Tom Son,Y Chen,Ann Easton,Jonathan C. Li,Jill Rillema,Monica Licea,Claudia B. Fieger,Tony W. Liang,Jennie P. Mather,Scott Koenig,Stanford J. Stewart,Syd Johnson,Ezio Bonvini,Paul A. Moore +23 more
TL;DR: Evaluation of MGA271 clinical utility in B7-H3–expressing cancer is supported, while validating a combination of a nontarget biased approach of intact cell immunizations and immunohistochemistry to identify novel cancer antigens with Fc-based mAb engineering to enable potent antitumor activity.
Journal ArticleDOI
CAT-8015: a second-generation pseudomonas exotoxin A-based immunotherapy targeting CD22-expressing hematologic malignancies.
Ralph Alderson,Robert J. Kreitman,Tianling Chen,Peter Yeung,Ronald Herbst,Judy A. Fox,Ira Pastan +6 more
TL;DR: CAT-8015 is a CD22-targeting immunotoxin that, in preclinical studies, has greatly improved efficacy compared with CAT-3888.
Journal ArticleDOI
MGD011, A CD19 x CD3 Dual-Affinity Retargeting Bi-specific Molecule Incorporating Extended Circulating Half-life for the Treatment of B-Cell Malignancies
Liqin Liu,Chia-Ying K Lam,Vatana Long,Lusiana Widjaja,Yinhua Yang,Hua Li,Linda Jin,Steve Burke,Sergey Gorlatov,Jennifer R. Brown,Ralph Alderson,Margaret D Lewis,Jeffrey L. Nordstrom,Scott Koenig,Paul A. Moore,Syd Johnson,Ezio Bonvini +16 more
TL;DR: The preclinical activity, safety and PK profile support clinical investigation of MGD011 as a therapeutic candidate for the treatment of B-cell malignancies.
Patent
Bi-specific monovalent diabodies that are capable of binding to gpa33 and cd3, and uses thereof
Ezio Bonvini,Leslie S. Johnson,Ling Huang,Paul A. Moore,Gurunadh Reddy Chichili,Ralph Alderson +5 more
TL;DR: In this article, a sequence-optimized CD 123 x CD3 bi-specific monovalent diabodies that are capable of simultaneous binding to CD 123 and CD3 are presented.
Journal ArticleDOI
Characterization of the 3,3',5-triiodo-L-thyronine-binding site on plasma membranes from human placenta.
TL;DR: It is demonstrated that a high affinity binding site specific for T3 is present on plasma membranes from human placenta and that the binding site is a protein, most likely a dimer, with a native mol wt between 140,000 and 150,000.