R
Ralph E. Wilson
Researcher at National Institutes of Health
Publications - 51
Citations - 2574
Ralph E. Wilson is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Toxicity & Pregnancy. The author has an hindex of 23, co-authored 51 publications receiving 2366 citations. Previous affiliations of Ralph E. Wilson include University of North Carolina at Chapel Hill & Research Triangle Park.
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Journal ArticleDOI
Role of proinflammatory cytokines in acetaminophen hepatotoxicity.
TL;DR: Data suggest that TNF-alpha and IL-1 alpha are released in response to APAP intoxication and are responsible for certain pathological manifestations of APAP-induced hepatotoxicity.
Journal ArticleDOI
The effects of perinatal/juvenile methoxychlor exposure on adult rat nervous, immune, and reproductive system function.
Robert E. Chapin,Martha W. Harris,B. J. Davis,Sandra M. Ward,Ralph E. Wilson,M. A. Mauney,Ann C. Lockhart,Ralph J. Smialowicz,Virginia C. Moser,Leo T. Burka,B Collins +10 more
TL;DR: The data collectively show that the primary adult effects of early exposure to MXC are reproductive, show that 5 mg/kg/day is not a NO(A)EL in rats with this exposure paradigm, and imply that the sites of action are both central and peripheral.
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Preconceptional fasting of fathers alters serum glucose in offspring of mice.
Lucy M. Anderson,Lisa Riffle,Ralph E. Wilson,Gregory S. Travlos,Mariusz S. Lubomirski,W. Gregory Alvord +5 more
TL;DR: Paternal food deprivation resulted in a consistent decrease in average serum glucose in male and female offspring, indicating a male-mediated transgenerational effect on metabolism- and growth-related parameters, in particular glucose.
Journal ArticleDOI
Histopathology of Acetaminophen-Induced Liver Changes: Role of Interleukin 1α and Tumor Necrosis Factor α:
TL;DR: It is suggested that TNF-α and IL-1α play an important role in the degree of damage and recovery that the liver undergoes following APAP intoxication.
Journal ArticleDOI
Blood gene expression signatures predict exposure levels
Pierre R. Bushel,Alexandra N. Heinloth,Jianying Li,Li-Yen Huang,Jeff W. Chou,Gary A. Boorman,David E. Malarkey,C. D. Houle,Sandra M. Ward,Ralph E. Wilson,Rickie D. Fannin,Mark W. Russo,Paul B. Watkins,Raymond W. Tennant,Richard S. Paules +14 more
TL;DR: The hypothesis that gene expression data from peripheral blood cells can provide valuable information about exposure levels, well before liver damage is detected by classical parameters, supports the potential use of genomic markers in the blood as surrogates for clinical markers of potential acute liver damage.