Journal ArticleDOI
Role of proinflammatory cytokines in acetaminophen hepatotoxicity.
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TLDR
Data suggest that TNF-alpha and IL-1 alpha are released in response to APAP intoxication and are responsible for certain pathological manifestations of APAP-induced hepatotoxicity.About:
This article is published in Toxicology and Applied Pharmacology.The article was published on 1995-07-01. It has received 323 citations till now. The article focuses on the topics: Proinflammatory cytokine & Kupffer cell.read more
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Journal ArticleDOI
Acetaminophen-induced hepatotoxicity
TL;DR: The recent finding that NADPH oxidase knockout mice were equally sensitive to acetaminophen and had equal nitration of tyrosine suggests that the superoxide is not from the activation of Kupffer cells.
Journal ArticleDOI
Obesity increases sensitivity to endotoxin liver injury: Implications for the pathogenesis of steatohepatitis
TL;DR: It is demonstrated that hepatic macrophage dysfunction occurs in obesity and suggested that this might promote steatohepatitis by sensitizing hepatocytes to endotoxin.
Book ChapterDOI
Mechanisms of Acetaminophen-Induced Liver Necrosis
TL;DR: The mechanism occurs by a complex sequence of events including: (1) CYP metabolism to a reactive metabolite which depletes glutathione and covalently binds to proteins; (2) loss of glutathion with an increased formation of reactive oxygen and nitrogen species in hepatocytes undergoing necrotic changes; (3) increased oxidative stress, associated with alterations in calcium homeostasis and initiation of signal transduction responses, causing mitochondrial permeability transition; (4) mitochondrial membrane potential, and loss of the ability of the mitochondria to synthesize ATP; and
Book ChapterDOI
Drug-induced liver injury.
Michael P. Holt,Changqing Ju +1 more
TL;DR: It is hoped that this chapter will shed light on the major problems associated with DILI in regards to the pharmaceutical industry, drug regulatory agencies, physicians and pharmacists, and patients.
Journal ArticleDOI
Paracetamol (acetaminophen)-induced toxicity: molecular and biochemical mechanisms, analogues and protective approaches.
TL;DR: An overview is presented on the molecular aspects of toxicity due to paracetamol (acetaminophen) and structural analogues, with emphasis on four main topics, that is, bioactivation, detoxication, chemoprevention, and chemoprotection.