R
Ramaswamy Nilakantan
Researcher at American Cyanamid
Publications - 19
Citations - 1391
Ramaswamy Nilakantan is an academic researcher from American Cyanamid. The author has contributed to research in topics: Pharmacophore & Heuristic. The author has an hindex of 13, co-authored 19 publications receiving 1342 citations. Previous affiliations of Ramaswamy Nilakantan include Columbia University.
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Topologial torsion: A new molecular descriptor for sar applications. Comparison with other descriptors
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The ensemble approach to distance geometry: application to the nicotinic pharmacophore.
TL;DR: An extension of conventional distance geometry techniques that treats two or more molecules as a single "ensemble" can be used to find a common pharmacophore, i.e., the spatial arrangement of essential groups, from a small set of biologically active molecules.
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Cloning and characterization of a sixth adenylyl cyclase isoform: types V and VI constitute a subgroup within the mammalian adenylyl cyclase family.
S. Katsushika,Liang Chen,Jun-ichi Kawabe,Ramaswamy Nilakantan,Nancy Halnon,Charles J. Homcy,Yoshihiro Ishikawa +6 more
TL;DR: Comparison of both their structural and biochemical properties suggests that types V and VI constitute a distinct subgroup of the mammalian adenylyl cyclase family.
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Calicheamicin gamma 1I and DNA: molecular recognition process responsible for site-specificity
TL;DR: It is proposed that the cutting specificity is due to a combination of the complementarity of the diyne-ene portion of the aglycone with DNA secondary structures and stabilization by association of the thiobenzoate-carbohydrate tail with the minor groove.