scispace - formally typeset
Search or ask a question

Showing papers by "Ranjan Deka published in 2016"

Journal Article•DOI•
A thrifty variant in CREBRF strongly influences body mass index in Samoans.

[...]

Ryan L. Minster1, Nicola L. Hawley2, Chi-Ting Su3, Chi-Ting Su1, Guangyun Sun4, Erin E. Kershaw1, Hong Cheng4, Olive D. Buhule1, Jerome Lin1, Muagututi‘a Sefuiva Reupena, Satupa‘itea Viali5, John Tuitele, Take Naseri, Zsolt Urban1, Ranjan Deka4, Daniel E. Weeks1, Stephen T. McGarvey6 •
University of Pittsburgh1, Yale University2, National Institutes of Health3, University of Cincinnati Academic Health Center4, National Health Service5, Brown University6
01 Sep 2016-Nature Genetics
TL;DR: A genome-wide association study in 3,072 Samoans discovered a variant strongly associated with body mass index (BMI) and evidence of positive selection of the allele encoding p.Arg457Gln, support a 'thrifty' variant hypothesis as a factor in human obesity.
Abstract: Stephen McGarvey and colleagues identify a missense variant in CREBRF strongly associated with body mass index in Samoans. This variant is rare in other populations but is common in Samoans and has a much larger effect size than other known common obesity risk variants, including variation in FTO.

204 citations