Showing papers by "Raul D. Santos published in 2008"
TL;DR: There was no difference in CAC progression or changes in bone remodeling between the calcium and the sevelamer groups.
Abstract: Background and Aims: Calcium-containing phosphate binders have been shown to increase the progression of vascular calcification in hemodialysis patients. This is a
158 citations
TL;DR: Lower trabecular bone volume was associated with CAC development, whereas improvement in bone turnover was associatedwith lower CAC progression in patients with high- and low-turnover bone disorders.
122 citations
TL;DR: The data indicate that isolated apoA-I deficiency results in marked HDL deficiency with very low apOA-II α-3 HDL particles, modest reductions in the separate and distinct plasma apo-IV and apoE HDL particle levels, tuboeruptive xanthomas, premature coronary atherosclerosis, and no evidence of fat malabsorption.
60 citations
TL;DR: Clinical parameters poorly explained IMT, CAC and PWV variability in FH subjects, and imaging markers and inflammatory biomarkers presented a poor agreement degree of their severity for CHD prediction.
54 citations
TL;DR: The data suggest that CTCA could be a useful non-invasive method for detection of early aortic and coronary atherosclerosis specifically affecting the coronary ostia in HoFH subjects.
37 citations
TL;DR: A framework for diagnosing the inherited causes of marked high-density lipoprotein (HDL) deficiency is provided and information about coronary heart disease (CHD) risk for such cases is provided.
34 citations
TL;DR: The notion that a favorable CVD profile is associated with less underlying atherosclerosis and inflammation is supported and the importance of primary prevention of CVRFs is highlighted.
Abstract: Middle-aged individuals with favorable levels of all major cardiovascular risk factors (CVRFs) have much lower age-specific risks for incident cardiovascular disease (CVD). However, the relationship of the absence of CVRFs with subclinical CVD and inflammation is not well described. We classified 440 asymptomatic Brazilian men (aged 46+/-7 years) based on the number of CVRFs (smoking, systolic blood pressure > or =130 mm Hg, low-density lipoprotein cholesterol > or =130 mg/dL, high-density lipoprotein cholesterol or =150 mg/dL, fasting glucose > or =100 mg/dL, and waist circumference >102 cm). Only 7% had no CVRFs, whereas 1, 2, 3, and > or =4 CVRFs were observed in 18%, 24%, 21%, and 29%, respectively. In age-adjusted analysis, each lower CVRF profile was associated with lower odds of prevalent coronary artery calcium (odds ratio, 0.75; P=.002) and elevated white blood cell count (odds ratio, 0.70; P<.001). Our study supports the notion that a favorable CVD profile is associated with less underlying atherosclerosis and inflammation and further highlights the importance of primary prevention of CVRFs.
8 citations
TL;DR: The finding of an interaction between SBP and LDL-C relation to CAC in asymptomatic men support the response-to-injury model of atherogenesis.
4 citations