R
Ravichandran Sankaranarayanan
Publications - 1
Citations - 95
Ravichandran Sankaranarayanan is an academic researcher. The author has contributed to research in topics: In vivo & Azepine. The author has an hindex of 1, co-authored 1 publications receiving 84 citations.
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Discovery, Design, and Optimization of Isoxazole Azepine BET Inhibitors
Victor S. Gehling,Michael C. Hewitt,Rishi G. Vaswani,Yves Leblanc,Alexandre Côté,Christopher G. Nasveschuk,Alexander M. Taylor,Jean-Christophe Harmange,James E. Audia,Eneida Pardo,Shivangi Joshi,Peter Sandy,Jennifer A. Mertz,Robert J. Sims,Louise Bergeron,Barbara M. Bryant,Steve Bellon,Florence Poy,Hariharan Jayaram,Ravichandran Sankaranarayanan,Sreegouri Yellapantula,Nandana Bangalore Srinivasamurthy,Swarnakumari Birudukota,Brian K. Albrecht +23 more
TL;DR: A structure-based drug design effort lead to a novel isoxazole azepine scaffold that showed good potency in biochemical and cellular assays and oral activity in an in vivo model of BET inhibition.