Raymond Bonnett

TL;DR: It is suggested that threshold conditions operate in PDT and have important implications for clinical application of the treatment, as well as the cross‐sectional area of tumour necrosis per depth of visible tissue injury at the control site.

TL;DR: Isoindole is a white solid which becomes discolored and resinous at room temperature, especially in the presence of air as discussed by the authors, and exhibits a series of strong bands in the near ultraviolet region extending in cases of further conjugation almost into the visible region.

Abstract: The oxidative cleavage of haemin in aqueous pyridine under various conditions (ascorbic acid–oxygen; hydrazine–oxygen; and ascorbic acid–hydrogen peroxide) gives four isomeric biliverdins of the IX series which have been isolated (from a much improved ascorbic acid–oxygen reaction) as their crystalline dimethyl esters. The properties of the four isomers are described. On the basis of mass and n.m.r. spectra, structures are assigned to all four isomers for the first time. A key observation in the n.m.r. spectra of these compounds is the chemical shift of the heteroaryl methyl group. The implications of these results are discussed.

TL;DR: There have been increasing efforts to turn the photodynamic effect to good use as the basis of a phototherapy for cancer, and some of these photosensitizers, especially the hydroporphyrins, look quite promising.

TL;DR: Nanosecond laser flash photolysis and pulse radiolysis have been used to generate and characterise the triplet state, and semioxidised and semireduced radicals of haematoporphyrin and three 0‐acyl compounds derived from it.