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Read R. Taintor
Researcher at University of Utah
Publications - 15
Citations - 6844
Read R. Taintor is an academic researcher from University of Utah. The author has contributed to research in topics: Cytotoxic T cell & Macrophage. The author has an hindex of 14, co-authored 15 publications receiving 6755 citations. Previous affiliations of Read R. Taintor include Duke University & Veterans Health Administration.
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Journal ArticleDOI
Nitric oxide: a cytotoxic activated macrophage effector molecule.
TL;DR: The results suggest that nitric oxide is the precursor of nitrite/nitrate synthesized by cytotoxic activated macrophages and, via formation of iron-nitric oxide complexes and subsequent degradation of Iron-sulfur prosthetic groups, an effector molecule.
Journal ArticleDOI
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite.
TL;DR: An L-arginine-dependent biochemical pathway synthesizing L-citrulline and nitrite, coupled to an effector mechanism, is shown to cause this pattern of metabolic inhibition in cytotoxic activated macrophages.
Journal Article
L-arginine is required for expression of the activated macrophage effector mechanism causing selective metabolic inhibition in target cells.
TL;DR: The results show that the inhibitory effect of these guanidino methylated derivatives of L-arginine is highly determined by structure and does not appear to be for protein synthesis, creatine biosynthesis, polyamine biosynthetic, or ADP ribosylation reactions.
Journal ArticleDOI
Evidence for cytokine-inducible nitric oxide synthesis from L-arginine in patients receiving interleukin-2 therapy.
John B. Hibbs,Christof Westenfelder,Read R. Taintor,Zdenek Vavrin,C. Kablitz,R. L. Baranowski,John H. Ward,R. L. Menlove,M. P. McMurry,James P. Kushner +9 more
TL;DR: Results showing increased endogenous nitrate synthesis in patients receiving IL-2 demonstrate for the first time that a cytokine-inducible, high-output L-arginine/NO pathway exists in humans.