R
Rebecca Haffner
Researcher at Weizmann Institute of Science
Publications - 10
Citations - 2115
Rebecca Haffner is an academic researcher from Weizmann Institute of Science. The author has contributed to research in topics: Wild type & Gene. The author has an hindex of 8, co-authored 10 publications receiving 2062 citations.
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Journal ArticleDOI
mdm2 expression is induced by wild type p53 activity.
TL;DR: It is suggested that the mdm2 gene is a target for activation by wt p53, and the induction of mDM2 expression by t p53 activity is at the mRNA level, suggesting a direct involvement of p53 in the process.
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Biochemical properties and biological effects of p53.
Rebecca Haffner,Moshe Oren +1 more
TL;DR: The high-resolution three-dimensional structure has been determined for the central core and carboxy-terminal domain of the p53 protein and insight has been gained into the relationship between p53-mediated growth arrest and apoptosis.
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Down-regulation of wild-type p53 activity interferes with apoptosis of IL-3-dependent hematopoietic cells following IL-3 withdrawal.
TL;DR: It is proposed that p53 is a positive, though not exclusive, mediator of survival factor dependence in hematopoietic cells.
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Transgenic mouse model for studying the transcriptional activity of the p53 protein: age- and tissue-dependent changes in radiation-induced activation during embryogenesis.
TL;DR: The activation potential of p53 is tightly controlled in vivo, both spatially and temporally, and an important element in this control is the presence of limiting basal levels of activatable p53.
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A proline-rich motif in p53 is required for transactivation- independent growth arrest as induced by Gas1
Elisabetta Ruaro,Licio Collavin,Giannino Del Sal,Rebecca Haffner,Moshe Oren,Arnold J. Levine,Claudio Schneider +6 more
TL;DR: A p53-dependent pathway initiated by the gas1 product, a plasma membrane protein highly expressed during G0, which activates a transactivation-independent p53 growth arrest function is identified, which relies on a proline-rich region of murine p53 in the transmission of antiproliferative signals.