R
Reini Hurme
Publications - 16
Citations - 1198
Reini Hurme is an academic researcher. The author has contributed to research in topics: Framingham Risk Score & Hazard ratio. The author has an hindex of 10, co-authored 16 publications receiving 903 citations.
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Journal ArticleDOI
Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol.
Reijo Laaksonen,Kim Ekroos,Marko Sysi-Aho,Mika Hilvo,Terhi Vihervaara,Dimple Kauhanen,Matti Suoniemi,Reini Hurme,Winfried März,Hubert Scharnagl,Tatjana Stojakovic,Efthymia Vlachopoulou,Marja-Liisa Lokki,Markku S. Nieminen,Roland Klingenberg,Christian M. Matter,Thorsten Hornemann,Peter Jüni,Nicolas Rodondi,Lorenz Räber,Stephan Windecker,Baris Gencer,Eva Ringdal Pedersen,Grethe S. Tell,Ottar Nygård,François Mach,Juha Sinisalo,Thomas F. Lüscher +27 more
TL;DR: Distinct plasma ceramide ratios are significant predictors of CV death both in patients with stable CAD and ACS, over and above currently used lipid markers.
Journal ArticleDOI
Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort.
Aki S. Havulinna,Marko Sysi-Aho,Mika Hilvo,Dimple Kauhanen,Reini Hurme,Kim Ekroos,Veikko Salomaa,Reijo Laaksonen +7 more
TL;DR: Distinct serum ceramides are associated with the risk of incident MACE in apparently healthy individuals and should encourage more detailed analyses of ceramide in cardiovascular pathobiology and suggest new biomarkers of MACE risk.
Journal ArticleDOI
Molecular Lipids Identify Cardiovascular Risk and Are Efficiently Lowered by Simvastatin and PCSK9 Deficiency
Kirill Tarasov,Kim Ekroos,Matti Suoniemi,Dimple Kauhanen,Tuulia Sylvänne,Reini Hurme,Ioanna Gouni-Berthold,Heiner K. Berthold,Marcus E. Kleber,Reijo Laaksonen,Winfried März,Winfried März,Winfried März +12 more
TL;DR: Data suggest that distinct ceramides associate significantly with CAD outcome independently of traditional risk factors and that the mechanism of lipid lowering is important.
Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort
Aki S. Havulinna,Marko Sysi-Aho,Mika Hilvo,Dimple Kauhanen,Reini Hurme,Kim Ekroos,Veikko Salomaa,Reijo Laaksonen +7 more
TL;DR: In this paper, the authors examined whether ceramides are associated with major adverse cardiovascular events (MACEs) among apparently healthy individuals and found that ceramide species had the strongest association with incident MACE and the highest unadjusted hazard ratio of 1.31 (95% confidence interval, 1.21-1.41).
Journal ArticleDOI
Lipidomics: a tool for studies of atherosclerosis
TL;DR: Improved patient selection, biomarkers for gauging treatment efficacy and safety, and translational models will be facilitated by the lipidomic deliverables, and lipid-based biomarkers and targets should lead the way as the authors progress toward more specialized therapeutics.