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Open AccessJournal ArticleDOI

Plasma ceramides predict cardiovascular death in patients with stable coronary artery disease and acute coronary syndromes beyond LDL-cholesterol.

Reijo Laaksonen, +27 more
- 01 Jul 2016 - 
- Vol. 37, Iss: 25, pp 1967-1976
TLDR
Distinct plasma ceramide ratios are significant predictors of CV death both in patients with stable CAD and ACS, over and above currently used lipid markers.
Abstract: 
All authors:Reijo Laaksonen, Kim Ekroos, Marko Sysi-Aho, Mika Hilvo, Terhi Vihervaara, Dimple Kauhanen, Matti Suoniemi, Reini Hurme, Winfried Marz, Hubert Scharnagl, Tatjana Stojakovic, Efthymia Vlachopoulou, Marja-Liisa Lokki, Markku S. Nieminen, Roland Klingenberg, Christian M. Matter, Thorsten Hornemann, Peter Juni, Nicolas Rodondi, Lorenz Raber, Stephan Windecker, Baris Gencer, Eva Ringdal Pedersen, Grethe S. Tell, Ottar Nygard, Francois Mach, Juha Sinisalo, Thomas F. Lusche

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Citations
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Journal ArticleDOI

2019 ESC Guidelines for the diagnosis and management of chronic coronary syndromes.

Juhani Knuuti, +24 more
- 14 Jan 2020 - 
TL;DR: In this article, the authors present guidelines for the management of patients with coronary artery disease (CAD), which is a pathological process characterized by atherosclerotic plaque accumulation in the epicardial arteries.
Journal ArticleDOI

Targeting a ceramide double bond improves insulin resistance and hepatic steatosis.

Bhagirath Chaurasia, +35 more
- 26 Jul 2019 - 
TL;DR: Mechanistic studies revealed ceramide actions that promoted lipid uptake and storage and impaired glucose utilization, none of which could be recapitulated by (dihydro)ceramides that lacked the critical double bond, suggest that inhibition of DES1 may provide a means of treating hepatic steatosis and metabolic disorders.
Journal ArticleDOI

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort.

Aki S. Havulinna, +7 more
- 01 Jan 2016 - 
TL;DR: Distinct serum ceramides are associated with the risk of incident MACE in apparently healthy individuals and should encourage more detailed analyses of ceramide in cardiovascular pathobiology and suggest new biomarkers of MACE risk.
Journal ArticleDOI

Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea).

Dong D. Wang, +24 more
- 09 Mar 2017 - 
TL;DR: A novel positive association between baseline plasma ceramide concentrations and incident CVD is documented and a Mediterranean dietary intervention may mitigate potential deleterious effects of elevated plasma ceramides on CVD.
Journal ArticleDOI

High-Throughput Plasma Lipidomics: Detailed Mapping of the Associations with Cardiometabolic Risk Factors.

Kevin Huynh, +10 more
- 17 Jan 2019 - 
TL;DR: A chromatography gradient coupled with a detailed characterization of the human plasma lipidome is reported to provide improved resolution and identification of 636 lipid species, including previously unreported species, in a 15-min analysis.
References
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Journal ArticleDOI

2015 ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: Task Force for the Management of Acute Coronary Syndromes in Patients Presenting without Persistent ST-Segment Elevation of the European Society of Cardiology (ESC)

Marco Roffi, +18 more
- 01 Dec 2011 - 
TL;DR: The current guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation are based on the findings of the ESC Task Force on 12 March 2015.
Journal ArticleDOI

Evaluating the added predictive ability of a new marker: From area under the ROC curve to reclassification and beyond

Michael J. Pencina, +2 more
- 30 Jan 2008 - 
TL;DR: Two new measures, one based on integrated sensitivity and specificity and the other on reclassification tables, are introduced that offer incremental information over the AUC and are proposed to be considered in addition to the A UC when assessing the performance of newer biomarkers.
Journal ArticleDOI

2013 ESC guidelines on the management of stable coronary artery disease: the Task Force on the management of stable coronary artery disease of the European Society of Cardiology.

Gilles Montalescot, +68 more
- 07 Oct 2013 - 
TL;DR: The If Inhibitor Ivabradine in Patients With Coronary Artery Disease and Left Ventricular Dysfunction is evaluated as well as patients with Diabetes mellitus for Optimal management of Multivessel disease.
Journal ArticleDOI

ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation

Christian W. Hamm, +16 more
- 01 Feb 2012 - 
TL;DR: This paper presents a Randomized Assessment of Acute Coronary Syndrome Treatment of Intracoronary Stenting With Antithrombotic Regimen and Harmonizing Outcomes with RevasculariZatiON and Stents in Acute Myocardial Infarction.
Journal ArticleDOI

ESC Guidelines for the management of acute coronary syndromes in patients presenting without persistent ST-segment elevation: The Task Force for the management of acute coronary syndromes (ACS) in patients presenting without persistent ST-segment eleva...

Christian W. Hamm, +67 more
- 26 Aug 2011 - 
Related Papers (5)

Circulating Ceramides Predict Cardiovascular Outcomes in the Population-Based FINRISK 2002 Cohort.

Aki S. Havulinna, +7 more
- 01 Jan 2016 - 

Plasma Ceramides, Mediterranean Diet, and Incident Cardiovascular Disease in the PREDIMED Trial (Prevención con Dieta Mediterránea).

Dong D. Wang, +24 more
- 09 Mar 2017 - 

Plasma Ceramides Are Elevated in Obese Subjects With Type 2 Diabetes and Correlate With the Severity of Insulin Resistance

Jacob M. Haus, +9 more
- 01 Feb 2009 - 

Ceramides – Lipotoxic Inducers of Metabolic Disorders

Bhagirath Chaurasia, +1 more
- 01 Oct 2015 - 

Obesity-induced CerS6-dependent C16:0 ceramide production promotes weight gain and glucose intolerance.

Sarah M. Turpin, +16 more
- 07 Oct 2014 -