R
Ren Zhang
Researcher at Guangzhou University of Chinese Medicine
Publications - 15
Citations - 231
Ren Zhang is an academic researcher from Guangzhou University of Chinese Medicine. The author has contributed to research in topics: Apoptosis & Caspase 3. The author has an hindex of 6, co-authored 13 publications receiving 128 citations. Previous affiliations of Ren Zhang include University of California, Davis.
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Protective effects of baicalin on LPS-induced injury in intestinal epithelial cells and intercellular tight junctions
TL;DR: Baicalin has the capacity to protect IEC-6 cells and the intercellular tight junctions from LPS-induced injury and the mechanisms may be associated with inhibiting the production of inflammatory cytokines, and up-regulating the mRNA and protein expression of ZO-1.
Journal ArticleDOI
Dioscin suppresses hepatocellular carcinoma tumor growth by inducing apoptosis and regulation of TP53, BAX, BCL2 and cleaved CASP3
Guangxian Zhang,Xiancheng Zeng,Ren Zhang,Juan Liu,Weici Zhang,Yujun Zhao,Xiao-yuan Zhang,Zhixue Wu,Yuhui Tan,Yingya Wu,Biaoyan Du +10 more
TL;DR: Investigating the anti-HCC properties of dioscin in vitro and in vivo demonstrated that Dioscin inhibited proliferation of HCC cell lines in a dose-dependent manner, and displayed anticancer activity via up-regulating expression of TP53, BAX and CASP3 protein, as well as down- Regulating BCL2 in Bel-7402 cells.
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Baicalin Protects against TNF-α-Induced Injury by Down-Regulating miR-191a That Targets the Tight Junction Protein ZO-1 in IEC-6 Cells
TL;DR: Results indicate that baicalin exerts a protective effect on IEC-6 (rat small intestinal epithelial cells) cells against TNF-α-induced injury, which is at least partly via inhibiting the expression of miR-191a, thus increasing ZO-1 mRNA and protein levels.
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Berberine chloride suppresses non-small cell lung cancer by deregulating Sin3A/TOP2B pathway in vitro and in vivo
Jian Chen,Xiaofei Huang,Cheng Tao,Cheng Tao,Li Wang,Zide Chen,Xinping Li,Qiang Zeng,Qiang Zeng,Min Ma,Ren Zhang,Zhengzhi Wu +11 more
TL;DR: A new mechanism that BBC suppresses human NSCLC by deregulating Sin3A/TOP2B pathway, leading to DNA damage and apoptosis in human NSclC in vitro and in vivo is demonstrated.
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Demethyleneberberine induces cell cycle arrest and cellular senescence of NSCLC cells via c-Myc/HIF-1α pathway.
TL;DR: In this article, Demethyleneberberine (DMB) was used to suppress non-small cell lung cancer (NSCLC) cells in vitro and in vivo.