Renate Stirner

TL;DR: It is concluded that chronic uncontrolled HIV-infection is associated with elevated levels of MDSC, which potentially contribute to the impaired T-cell responses characteristic for the progressive disease stage.

TL;DR: MDSC from HIV-infected progressors restricted the proliferative capacity of CD8 T cells from healthy donors and of Gag/Nef-specific CD 8 T cellsFrom HIV-controllers in vitro in vitro.

TL;DR: GMDSC can be studied with delay, mMDSC however should be studied no later than 4 h after blood draw, and both MDSC subgroups became more difficult over time due to less sharp divisions between populations.

TL;DR: It is postulate that MDSC in peripheral blood are most likely not significant regarding immune dysfunction in cHEP-C, because of the low level of elevation in chronic hepatitis C patients.

TL;DR: In the treatment intensification subjects, the frequencies of the immune suppressive cells were comparable or lower than those of the conventional ART-treated subjects, with surprisingly broad HIV-specific CD8 T cell responses, suggesting a preservation of immune function with the applied treatment regimen.