R
Rency S. Varghese
Researcher at Georgetown University Medical Center
Publications - 70
Citations - 1989
Rency S. Varghese is an academic researcher from Georgetown University Medical Center. The author has contributed to research in topics: Biomarker discovery & Medicine. The author has an hindex of 21, co-authored 61 publications receiving 1732 citations. Previous affiliations of Rency S. Varghese include University of Maine & University of Washington.
Papers
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Proceedings ArticleDOI
Analysis of MALDI-TOF mass spectrometry data for detection of glycan biomarkers.
Habtom W. Ressom,Rency S. Varghese,Lenka Goldman,Christopher A. Loffredo,Mohamed Abdel-Hamid,Zuzana Kyselova,Yehia Mechref,Milos V. Novotny,Radoslav Goldman +8 more
TL;DR: The proposed framework enables a systematic selection of glycan structures that have good generalization capability in distinguishing subjects from two pre-labeled groups and describes a new approach that allows the selection of subgroup-specific glycans by searching for glycans that display differential abundance in a subgroup of patients only.
Proceedings ArticleDOI
Analysis of MALDI-TOF Serum Profiles for Biomarker Selection and Sample Classification
Habtom W. Ressom,Rency S. Varghese,E. Orvisky,Steven K. Drake,Glen L. Hortin,Mohamed Abdel-Hamid,Christopher A. Loffredo,Radoslav Goldman +7 more
TL;DR: This work presents data processing methods and computational intelligence that combines support vector machines (SVM) with particle swarm optimization (PSO) for biomarker selection from MALDI-TOF spectra of enriched serum and identified mass points that achieved high classification accuracy in distinguishing cancer patients from non-cancer controls.
Proceedings ArticleDOI
Ant colony optimization for biomarker identification from MALDI-TOF mass spectra.
Habtom W. Ressom,Rency S. Varghese,Eduard Orvisky,Steven K. Drake,Glen L. Hortin,Mohamed Abdel-Hamid,Christopher A. Loffredo,Radoslav Goldman +7 more
TL;DR: The results indicate that the MALDI-TOF technology could provide the means to discover novel biomarkers for HCC.
Journal ArticleDOI
Functional Proteomics Analysis to Study ATM Dependent Signaling in Response to Ionizing Radiation
Amrita K. Cheema,Rency S. Varghese,Olga A. Timofeeva,Lihua Zhang,Alexander Kirilyuk,Fereshteh Zandkarimi,Prabhjit Kaur,Habtom W. Ressom,Mira Jung,Anatoly Dritschilo +9 more
TL;DR: Functional pathway analysis shows robust translational and post-translational responses under ATM proficient conditions, which include enrichment of proteins in the Ephrin receptor and axonal guidance signaling pathways.
Journal ArticleDOI
Transcriptome of rhesus macaque (Macaca mulatta) exposed to total-body irradiation.
Yaoxiang Li,Jatinder Singh,Rency S. Varghese,Yubo Zhang,Oluseyi O. Fatanmi,Amrita K. Cheema,Vijay K. Singh +6 more
TL;DR: In this article, the impact of gamma-irradiation on alterations in blood-based gene expression was studied using a nonhuman primate (NHP) model to identify biomarkers for radiation injury.