S
Steven K. Drake
Researcher at National Institutes of Health
Publications - 52
Citations - 3349
Steven K. Drake is an academic researcher from National Institutes of Health. The author has contributed to research in topics: Peptide & Mass spectrometry. The author has an hindex of 25, co-authored 52 publications receiving 3093 citations. Previous affiliations of Steven K. Drake include Georgetown University.
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Journal ArticleDOI
Targeted deletion of the gene encoding iron regulatory protein-2 causes misregulation of iron metabolism and neurodegenerative disease in mice.
Timothy LaVaute,Sophia R. Smith,Sharon Cooperman,Kazuhiro Iwai,William Land,Esther G. Meyron-Holtz,Steven K. Drake,Georgina F. Miller,Mones Abu-Asab,Maria Tsokos,Robert Switzer,Alexander Grinberg,Paul E. Love,Nancy Tresser,Tracey A. Rouault +14 more
TL;DR: Mice generated with a targeted disruption of the gene encoding Irp2 (Ireb2) misregulate iron metabolism in the intestinal mucosa and the central nervous system and may contribute to the pathogenesis of comparable human neurodegenerative diseases.
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Rapid identification of bacteria in positive blood culture broths by matrix-assisted laser desorption ionization-time of flight mass spectrometry.
TL;DR: This method provides a rapid, accurate, definitive identification of bacteria within 1 h of detection in positive blood cultures with the caveat that the identification of S. pneumoniae would have to be confirmed by an alternative test.
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Iron-dependent oxidation, ubiquitination, and degradation of iron regulatory protein 2: Implications for degradation of oxidized proteins
Kazuhiro Iwai,Steven K. Drake,Nancy B. Wehr,Allan M. Weissman,Timothy LaVaute,Nagahiro Minato,Richard D. Klausner,Rodney L. Levine,Tracey A. Rouault +8 more
TL;DR: It is demonstrated that iron regulatory protein 2 (IRP2) is oxidized and ubiquitinated in cells before degradation, and iron-dependent oxidation converts IRP2 into a substrate for ubiquitination in vitro.
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Identification of Mycobacteria in Solid-Culture Media by Matrix-Assisted Laser Desorption Ionization–Time of Flight Mass Spectrometry
TL;DR: It is concluded that MALDI-TOF MS analysis can be incorporated into the work flow of the microbiology laboratory for rapid and accurate identification of most strains of mycobacteria isolated from solid growth media.
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Evaluation of Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry for Identification of Clinically Important Yeast Species
TL;DR: The MALDI-TOF MS-based method was found to be reproducible and accurate, with low consumable costs and minimal preparation time.