Showing papers by "René Adam published in 1994"
TL;DR: Immunological circadian rhythms appear to be maintained in liver transplant patients receiving continuous infused immunosuppressive therapy, however, rhythms were altered in patients with advanced stage malignancy or HIV infection, and in cancer patients receiving infusions of cytokines on a standard regimen.
Abstract: Activation, proliferation and circulation of immune cells vary predictably according to circadian (approximately 24-hour) rhythms. These biological rhythms are endogenous and genetically based. Rhythms in nocturnally active experimental animals such as mice or rats are 12 hours out of phase from those in diurnally active humans. In animal studies, the toxic and immunomodulatory effects of agents such as interferon, interleukin-2 and cyclosporin can vary by 50% or more according to time of administration, presumably as a result of circadian rhythms.
13 citations
01 Feb 1994
8 citations
TL;DR: Glycogen levels are low in these organs, and NTP synthesis must be from substrates other than fatty acids, and Livers from fed mice show an improved recovery after cold ischemia.
5 citations
TL;DR: The experimental approach described here opens up the possibility of measuring changes of the 31P profile on the same liver during the whole transplantation procedure, i.e., in the donor, during preservation and after transplantation, and comparing evolution of spectra with transplantation outcome.
Abstract: An experimental approach was evaluated to perform a follow-up of rat liver transplantation by 31 P spectroscopy. The approach is based on the use of an implanted surface coil attached to the liver and inductively coupled to the receiver/transmitter line by an external coupling loop. Spatial localization to the liver was performed by selective excitation and dephasing of spins in a slice between the implanted and the coupling coil, the slice being positioned on a proton image acquired prior to spectroscopy. Characteristics of the protocol were established on a phantom and in vivo on non-transplanted rat livers indicating good localization and high signal-to-noise ratio. Preliminary results obtained on transplanted livers revealed a relation between evolution of the 31 P spectrum and animal survival. As shown in separate experiments, the same technique also enabled easy acquisition of the 31 P profile of livers stored at 4 °C in University of Wisconsin solution. Therefore, the experimental approach described here opens up the possibility of measuring changes of the 31 P profile on the same liver during the whole transplantation procedure, i.e., in the donor, during preservation and after transplantation, and comparing evolution of spectra with transplantation outcome.
3 citations