R
Rene Jackstadt
Researcher at Ludwig Maximilian University of Munich
Publications - 41
Citations - 2657
Rene Jackstadt is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Colorectal cancer & Metastasis. The author has an hindex of 16, co-authored 32 publications receiving 2040 citations. Previous affiliations of Rene Jackstadt include German Cancer Research Center.
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Journal ArticleDOI
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Matjaz Rokavec,Meryem Gülfem Öner,Huihui Li,Rene Jackstadt,Longchang Jiang,Dmitri Lodygin,Markus Kaller,David Horst,Paul Ziegler,Sarah Schwitalla,Julia Slotta-Huspenina,Franz G. Bader,Florian R. Greten,Heiko Hermeking +13 more
TL;DR: Exposure of human colorectal cancer cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron, indicating that p53-dependent expression of miR-34a suppresses tumor progression by inhibiting a IL- 6R/STAT3/miR- 34a feedback loop.
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miR-34 and SNAIL form a double-negative feedback loop to regulate epithelial-mesenchymal transitions.
Helge Siemens,Rene Jackstadt,Sabine Hünten,Markus Kaller,Antje Menssen,Ursula Götz,Heiko Hermeking +6 more
TL;DR: The frequent inactivation of p53 and/or miR-34a/b/c found in cancer may shift the equilibrium of these reciprocal regulations towards the mesenchymal state and thereby lock cells in a metastatic state.
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SNAIL and miR-34a feed-forward regulation of ZNF281/ZBP99 promotes epithelial–mesenchymal transition
TL;DR: ZNF281 is identified as a component of EMT‐regulating networks, which contribute to metastasis formation in CRC and is associated with increased migration/invasion and enhanced β‐catenin activity.
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Detection of miR-34a promoter methylation in combination with elevated expression of c-Met and β-catenin predicts distant metastasis of colon cancer
Helge Siemens,Jens Neumann,Rene Jackstadt,Ulrich Mansmann,David Horst,Thomas Kirchner,Heiko Hermeking +6 more
TL;DR: Silencing of miR-34a and upregulation of c-Met, Snail, and β-catenin expression is associated with liver metastases of colon cancer.
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Repression of c-Kit by p53 is mediated by miR-34 and is associated with reduced chemoresistance, migration and stemness
TL;DR: C-Kit is established as a new direct target of miR-34 and this regulation interferes with several c-Kit-mediated effects on cancer cells, and may be potentially relevant for future diagnostic and therapeutic approaches.