Huihui Li

TL;DR: Exposure of human colorectal cancer cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron, indicating that p53-dependent expression of miR-34a suppresses tumor progression by inhibiting a IL- 6R/STAT3/miR- 34a feedback loop.

TL;DR: Delivery or re-expression of miR-34 leads to notable repression of tumor growth and metastasis in cancer mouse models, and may therefore represent an efficient strategy for future cancer therapeutics.

TL;DR: A double-negative feedback loop involving miR-15a/16-1 and AP4 that stabilizes epithelial and mesenchymal states, respectively, which may determine metastatic prowess is reported.

TL;DR: Investigation of the expression and localization of protein phosphatase 1 regulatory inhibitor subunit 11 in 82 human colon cancers identified PPP1R11, whose product inhibits PP1, as a target of MIR34A, a targeted pathway to inhibit CRC metastasis and overcome resistance to therapy associated with hypoxia.

TL;DR: The state-of-the-art on the role of the p53-miRNA connection in gastrointestinal cancer is summarized and miRNA-based therapeutics may represent a feasible strategy for future cancer treatment.