M
Meryem Gülfem Öner
Researcher at Ludwig Maximilian University of Munich
Publications - 6
Citations - 819
Meryem Gülfem Öner is an academic researcher from Ludwig Maximilian University of Munich. The author has contributed to research in topics: Metastasis & microRNA. The author has an hindex of 5, co-authored 5 publications receiving 630 citations.
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Journal ArticleDOI
IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Matjaz Rokavec,Meryem Gülfem Öner,Huihui Li,Rene Jackstadt,Longchang Jiang,Dmitri Lodygin,Markus Kaller,David Horst,Paul Ziegler,Sarah Schwitalla,Julia Slotta-Huspenina,Franz G. Bader,Florian R. Greten,Heiko Hermeking +13 more
TL;DR: Exposure of human colorectal cancer cells to the cytokine IL-6 activates the oncogenic STAT3 transcription factor, which directly represses the MIR34A gene via a conserved STAT3-binding site in the first intron, indicating that p53-dependent expression of miR-34a suppresses tumor progression by inhibiting a IL- 6R/STAT3/miR- 34a feedback loop.
Journal ArticleDOI
Mitophagy in Intestinal Epithelial Cells Triggers Adaptive Immunity during Tumorigenesis
Paul K. Ziegler,Julia Bollrath,Charles K. Pallangyo,Takaji Matsutani,Özge Canli,Tiago De Oliveira,Michaela A. Diamanti,Nina Müller,Jaba Gamrekelashvili,Tracy L Putoczki,David Horst,Arun K. Mankan,Meryem Gülfem Öner,Susanna Müller,Josef Müller-Höcker,Thomas Kirchner,Thomas Kirchner,Julia Slotta-Huspenina,Makoto Mark Taketo,Thomas Reinheckel,Thomas Reinheckel,Stefan Dröse,Andrew C. Larner,Winfried S. Wels,Winfried S. Wels,Matthias Ernst,Tim F. Greten,Melek C. Arkan,Melek C. Arkan,Thomas Korn,Dagmar Wirth,Florian R. Greten,Florian R. Greten +32 more
TL;DR: This work unravels a complex intracellular process in intestinal epithelial cells (IECs) that controls the induction of a CD8+ T cell based adaptive immune response and highlights a so-far-unrecognized link between mitochondrial function, lysosomal integrity, and MHC class I presentation in IECs.
Journal ArticleDOI
lnflammation-induced epigenetic switches in cancer
TL;DR: This review summarizes published evidence of epigenetic switches in cancer development that are induced by inflammation that represent an important basis for the design of novel anticancer therapeutics.
Journal ArticleDOI
Corrigendum. IL-6R/STAT3/miR-34a feedback loop promotes EMT-mediated colorectal cancer invasion and metastasis
Journal ArticleDOI
Combined Inactivation of TP53 and MIR34A Promotes Colorectal Cancer Development and Progression in Mice Via Increasing Levels of IL6R and PAI1.
Meryem Gülfem Öner,Matjaz Rokavec,Markus Kaller,Nassim Bouznad,David Horst,Thomas Kirchner,Heiko Hermeking,Heiko Hermeking +7 more
TL;DR: It is demonstrated that combined inactivation of Mir34a and Tp53 promotes azoxymethane-induced colorectal carcinogenesis and tumor progression and metastasis by increasing levels of IL6R and PAI1.