René L. Warren

TL;DR: The data facilitated the first comparison of nucleotide diversity between the light and IG heavy (IGH) chain haplotypes within a single genome, revealing a three to six fold enrichment in the IGH locus, supporting the theory that the heavy chain may be more important in determining antigenic specificity.

TL;DR: TASR is presented, a streamlined assembler that interrogates very large NGS data sets for the presence of specific variants, by only considering reads within the sequence space of input target sequences provided by the user.

TL;DR: LINKS, the Long Interval Nucleotide K-mer Scaffolder algorithm, is presented, a solution that makes use of the information in error-rich long reads, without the need for read alignment or base correction, and is expected to have broad utility in harnessing the potential of long reads in connecting high-quality sequences of small and large genome assembly drafts.

TL;DR: Heterozygosity persisted at many loci, and nearly 100 loci were found to deviate from expectations of genetic drift, suggestive of associative overdominance, which may account for how WRC remains responsive to natural and artificial selection, despite low genetic diversity.

TL;DR: The current state-of-the-art read-to-read overlap tools for error-prone long reads, including BLASR, DALIGNER, MHAP, GraphMap, and Minimap are reviewed, highlighting the algorithmic features of these tools, as well as their potential issues and biases when utilizing any particular method.