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Richard K. Wilson
Researcher at Washington University in St. Louis
Publications - 10
Citations - 508
Richard K. Wilson is an academic researcher from Washington University in St. Louis. The author has contributed to research in topics: Breast cancer & Gene. The author has an hindex of 7, co-authored 10 publications receiving 340 citations.
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Visualizing tumor evolution with the fishplot package for R
Christopher A. Miller,Joshua F. McMichael,Ha X. Dang,Christopher G. Maher,Li Ding,Timothy J. Ley,Elaine R. Mardis,Richard K. Wilson +7 more
TL;DR: The simplicity, power, and flexibility of this tool make it valuable for visualizing tumor evolution, and it has potential utility in both research and clinical settings.
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The prognostic effects of somatic mutations in ER-positive breast cancer
Obi L. Griffith,Nicholas C. Spies,Meenakshi Anurag,Malachi Griffith,Jingqin Luo,Dongsheng Tu,Belinda Yeo,Jason Kunisaki,Christopher A. Miller,Kilannin Krysiak,Jasreet Hundal,Benjamin J. Ainscough,Zachary L. Skidmore,Katie M. Campbell,Runjun D. Kumar,Catrina Fronick,Lisa Cook,Jacqueline E. Snider,Sherri R. Davies,Shyam M. Kavuri,Eric C. Chang,Vincent Magrini,Vincent Magrini,David E. Larson,Robert S. Fulton,Shuzhen Liu,Samuel Leung,David Voduc,Ron Bose,Mitch Dowsett,Richard K. Wilson,Torsten O. Nielsen,Elaine R. Mardis,Matthew J. Ellis +33 more
TL;DR: Target sequencing of 83 genes using DNA from primary breast cancer samples from 625 postmenopausal and 328 premenopausal patients to determine interactions between somatic mutation and prognosis finds associations with clinical outcome for NF1 frame-shift nonsense mutations, PIK3R1 mutation, and DDR1 mutations.
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Genomic analysis reveals hidden biodiversity within colugos, the sister group to primates
Victor C. Mason,Gang Li,Patrick Minx,Jürgen Schmitz,Gennady Churakov,Liliya Doronina,Amanda D. Melin,Nathaniel J. Dominy,Norman T.-L. Lim,Norman T.-L. Lim,Mark S. Springer,Richard K. Wilson,Wesley C. Warren,Kristofer M. Helgen,William J. Murphy +14 more
TL;DR: Large genetic differences between many geographically isolated populations that may result in a >300% increase in the number of recognized colugo species are identified and conservation units to mitigate future losses of this enigmatic mammalian order are identified.
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Aromatase inhibition remodels the clonal architecture of estrogen-receptor-positive breast cancers
Christopher A. Miller,Yevgeniy Gindin,Charles Lu,Obi L. Griffith,Malachi Griffith,Dong Shen,Jeremy Hoog,Tiandao Li,David E. Larson,Mark A. Watson,Sherri R. Davies,Kelly K. Hunt,Vera J. Suman,Jacqueline E. Snider,Thomas J. Walsh,Graham A. Colditz,Katherine DeSchryver,Richard K. Wilson,Elaine R. Mardis,Matthew J. Ellis,Matthew J. Ellis +20 more
TL;DR: Comparing whole-genome sequencing of tumour/normal pairs from the two time points, with coincident tumour RNA sequencing, reveals widespread spatial and temporal heterogeneity, with marked remodelling of the clonal landscape in response to NAI.
Journal ArticleDOI
Sequencing of the human IG light chain loci from a hydatidiform mole BAC library reveals locus-specific signatures of genetic diversity
Corey T. Watson,Corey T. Watson,Karyn Meltz Steinberg,Karyn Meltz Steinberg,Tina Graves,René L. Warren,Maika Malig,Jacqueline E. Schein,Richard K. Wilson,Robert A. Holt,Evan E. Eichler,Evan E. Eichler,Felix Breden +12 more
TL;DR: Genetic diversity in IGK/IGL was compared with that of the IG heavy chain (IGH) locus within the same haploid genome, revealing threefold (IGK) and sixfold(IGL) higher diversity in the IGH locus, potentially associated with increased levels of segmental duplication and the telomeric location of IGH.