Rene Przkora

TL;DR: This review intends to give an overview of the current knowledge of pathophysiology and non-surgical therapies available for knee osteoarthritis.

TL;DR: After severe burn, a specific cytokine expression profile is observed in patients without complications such as inhalation injury or sepsis and the elevation in most serum cytokine levels during the first week after burn may indicate a potential window of opportunity for therapeutic intervention.

TL;DR: A comprehensive allelotype analysis of 466 nervous system tumors based on loss of heterozygosity studies with 129 microsatellite markers that span the genome points to several novel genetic loci associated with brain tumor development, demonstrate relationships between molecular changes and histopathological features, and further expand the concept of molecular tumor variants in neuro-oncology.

TL;DR: Female burned patients exert an attenuated inflammatory and hypermetabolic response compared with males, which is reflected in improved muscle protein net balance and preservation of lean body mass, which are associated with shortened hospital stay.

TL;DR: The utility of the burned mouse model for development of therapeutic interventions to attenuate the post-burn inflammatory response is confirmed, and temporal cytokine expression pattern elucidates the pathogenesis of the inflammatory response in burned mice.