R
Ruth Wellenreuther
Researcher at German Cancer Research Center
Publications - 27
Citations - 2212
Ruth Wellenreuther is an academic researcher from German Cancer Research Center. The author has contributed to research in topics: Meningioma & Gene. The author has an hindex of 20, co-authored 27 publications receiving 2112 citations. Previous affiliations of Ruth Wellenreuther include University of Bonn.
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Journal ArticleDOI
Systematic subcellular localization of novel proteins identified by large-scale cDNA sequencing
TL;DR: A novel cloning technology is used to rapidly generate N‐ and C‐terminal green fluorescent protein fusions of cDNAs to examine the intracellular localizations of >100 expressed fusion proteins in living cells.
Journal Article
Analysis of the neurofibromatosis 2 gene reveals molecular variants of meningioma.
Ruth Wellenreuther,Jürgen Kraus,D. Lenartz,Anil G. Menon,Johannes Schramm,David N. Louis,Vijaya Ramesh,James F. Gusella,Otmar D. Wiestler,A. von Deimling +9 more
TL;DR: In this paper, the authors analyzed the entire coding region of the NF2 gene in 70 sporadic meningiomas and identified 43 mutations in 41 patients, which resulted in immediate truncation, splicing abnormalities, or an altered reading frame of the predicted protein product.
Journal Article
Allelic Losses on Chromosomes 14, 10, and 1 in Atypical and Malignant Meningiomas: A Genetic Model of Meningioma Progression
Matthias Simon,Jeffrey J. Larson,Anil G. Menon,Ronald E. Warnick,John M. Tew,Andreas von Deimling,Ruth Wellenreuther,Peter Kaskel,Andreas Waha +8 more
TL;DR: Because LOH for loci on chromosomes 1p and 10q was found in tumors of all grades and because the frequency of LOH in all three regions increased with tumor grade, these results would support a model for the formation of aggressive meningiomas through tumor progression.
Journal ArticleDOI
Secretory meningiomas are defined by combined KLF4 K409Q and TRAF7 mutations.
David E. Reuss,Rosario M. Piro,Rosario M. Piro,David T.W. Jones,Matthias Simon,Ralf Ketter,Marcel Kool,Albert J. Becker,Felix Sahm,Stefan Pusch,Jochen Meyer,Christian Hagenlocher,Leonille Schweizer,David Capper,Phillipp Kickingereder,Jana Mucha,Christian Koelsche,Natalie Jäger,Thomas Santarius,Patrick S. Tarpey,Philip J. Stephens,P. Andrew Futreal,Ruth Wellenreuther,Jürgen Kraus,Doris Lenartz,Christel Herold-Mende,Christian Hartmann,Christian Mawrin,Nathalia A. Giese,Roland Eils,Roland Eils,V. Peter Collins,Rainer König,Rainer König,Otmar D. Wiestler,Stefan M. Pfister,Stefan M. Pfister,Andreas von Deimling +37 more
TL;DR: An essential contribution of combined KLF4 K409Q and TRAF7 mutations in the genesis of secretory meningioma is suggested and a role for TRAf7 alterations in other non-NF2 meningingiomas is demonstrated.
Journal ArticleDOI
Toward a Catalog of Human Genes and Proteins: Sequencing and Analysis of 500 Novel Complete Protein Coding Human cDNAs
Stefan Wiemann,Bernd Weil,Ruth Wellenreuther,Johannes Gassenhuber,Sabine Glassl,Wilhelm Ansorge,Michael Böcher,Helmut Blöcker,Stefan Bauersachs,Helmut Blum,Jürgen Lauber,A. Düsterhöft,Andreas Beyer,Karl Köhrer,Normann Strack,Hans-Werner Mewes,Birgit Ottenwälder,Brigitte Obermaier,Jens Tampe,Dagmar Heubner,R. Wambutt,Bernhard Korn,Michaela Klein,Annemarie Poustka +23 more
TL;DR: The sequencing and analysis of 500 novel human cDNAs containing the complete protein coding frame were reported, finding a number of genes that either had been completely missed in the analysis of the genomic sequences or had been wrongly predicted.