M
Marc G. Jeschke
Researcher at Sunnybrook Health Sciences Centre
Publications - 203
Citations - 15528
Marc G. Jeschke is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Hypermetabolism & Medicine. The author has an hindex of 64, co-authored 174 publications receiving 13903 citations. Previous affiliations of Marc G. Jeschke include University of Erlangen-Nuremberg & Universidade Federal de Minas Gerais.
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Journal ArticleDOI
Genomic responses in mouse models poorly mimic human inflammatory diseases
Seok Junhee Seok,Shaw Warren,G. Cuenca Alex,N. Mindrinos Michael,V. Baker Henry,Weihong Xu,Daniel R. Richards,Grace P. McDonald-Smith,Hong Gao,Laura Hennessy,Celeste C. Finnerty,Cecilia M Lopez,Shari Honari,Ernest E. Moore,Joseph P. Minei,Joseph Cuschieri,Paul E. Bankey,Jeffrey L. Johnson,Jason L. Sperry,Avery B. Nathens,Timothy R. Billiar,Michael West,Marc G. Jeschke,Matthew B. Klein,Richard L. Gamelli,Nicole S. Gibran,Bernard H. Brownstein,Carol L. Miller-Graziano,Steve E. Calvano,Philip H. Mason,J. Perren Cobb,Laurence G. Rahme,Stephen F. Lowry,Ronald V. Maier,Lyle L. Moldawer,David N. Herndon,Ronald W. Davis,Wenzhong Xiao,Wenzhong Xiao,Ronald G. Tompkins +39 more
TL;DR: This study shows that, although acute inflammatory stresses from different etiologies result in highly similar genomic responses in humans, the responses in corresponding mouse models correlate poorly with the human conditions and also, one another.
Journal ArticleDOI
Hypertrophic Scarring and Keloids: Pathomechanisms and Current and Emerging Treatment Strategies
TL;DR: The current understanding of the pathophysiology underlying keloid and hypertrophic scar formation is summarized and established treatments and novel therapeutic strategies are discussed.
Journal ArticleDOI
Pathophysiologic response to severe burn injury.
Marc G. Jeschke,David L. Chinkes,Celeste C. Finnerty,Gabriela A. Kulp,Oscar E. Suman,William B. Norbury,Ludwik K. Branski,Gerd G. Gauglitz,Ronald P. Mlcak,David N. Herndon +9 more
TL;DR: It is concluded that the postburn response is profound, occurring in a timely manner, with derangements that are greater and more protracted than previously thought.
Journal ArticleDOI
Long-Term Persistance of the Pathophysiologic Response to Severe Burn Injury
Marc G. Jeschke,Marc G. Jeschke,Gerd G. Gauglitz,Gerd G. Gauglitz,Gabriela A. Kulp,Celeste C. Finnerty,Felicia N. Williams,Robert Kraft,Oscar E. Suman,Ronald P. Mlcak,David N. Herndon +10 more
TL;DR: Severe burn injury leads to a much more profound and prolonged hypermetabolic and hyperinflammatory response than previously shown, and treatment needs for severely burned patients for a muchMore prolonged time are identified.
Journal ArticleDOI
Hypertrophic scarring: the greatest unmet challenge after burn injury.
Celeste C. Finnerty,Marc G. Jeschke,Marc G. Jeschke,Marc G. Jeschke,Ludwik K. Branski,Ludwik K. Branski,Juan P. Barret,Peter Dziewulski,Peter Dziewulski,David N. Herndon,David N. Herndon +10 more
TL;DR: The need for novel treatments is paramount, and future efforts to improve outcomes and quality of life should include optimisation of wound healing to attenuate or prevent hypertrophic scarring, well-designed trials to confirm treatment efficacy, and further elucidation of molecular mechanisms to allow development of new preventive and therapeutic strategies.