René Villadsen

TL;DR: It is concluded that the double-layered breast acinus may be recapitulated in culture and that one reason for the ability of myoepithelial cells to induce polarity is because they are the only source of laminin-1 in the breast in vivo.

TL;DR: MUC(-)/ESA(+) epithelial cells within the luminal epithelial lineage may function as precursor cells of terminal duct lobular units in the human breast.

TL;DR: An adult human breast ductal stem cell activity and its earliest descendants are identified and the four cell types assessed are constituents of an as of yet undescribed stem cell hierarchy.

TL;DR: It is concluded that breast cancer can generate its own nonmalignant stroma and that one function for this is that of a reciprocal interaction with epithelial tumor cells to facilitate tumor growth.

TL;DR: Microenvironment protein microarrays are used to functionally identify combinations of cell-extrinsic mammary gland proteins and ECM molecules that imposed specific cell fates on bipotent human mammary progenitor cells, and report on the functional ability of those proteins of the mammary glands that maintain quiescence, maintain the progenitors state, and guide progensitor differentiation towards myoepithelial and luminal lineages.