Reza Akbarzadeh

TL;DR: Despite a significant association between AA and HLA-DRB 1*11 frequencies, the presence of DRB1*11 is not associated with PTPN22, CTLA4, or IL2RA gene SNPs.

TL;DR: It is shown both in vitro and in vivo that immune complex-mediated neutrophil adhesion to the target tissue depends on β2 integrins, and that blocking of adhesion drastically inhibited tissue damage in an experimental model of autoantibody-mediated skin blistering disease.

TL;DR: It is confirmed that the IL12B and IL23R polymorphisms are associated with the risk to develop alopecia areata in the population of Iranian patients.

TL;DR: The results indicate that IL-13 rs1800925 variation may be a protective genetic marker for the development of BP and therapeutic strategies could potentially be developed interfering with the functions of IL- 13 cytokine, which seems to be integral in the pathogenesis of eosinophilic inflammatory disorders, such as BP.

TL;DR: Although higher expression levels of IL-8 gene was found in the patients compared with healthy controls, these levels suggest no association with the examined polymorphism, and further investigation revealed an elevation in gene expression between wild and polymorphic genotypes ofIL-1α and TNF-α in the patient group and these SNPs are therefore associated with altering the levels of gene expression.