T
Thomas Scholzen
Researcher at Max Planck Society
Publications - 33
Citations - 6115
Thomas Scholzen is an academic researcher from Max Planck Society. The author has contributed to research in topics: Cellular differentiation & Gene. The author has an hindex of 16, co-authored 32 publications receiving 5672 citations. Previous affiliations of Thomas Scholzen include Hamburg University of Technology & Thomas Jefferson University.
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Journal ArticleDOI
The Ki‐67 protein: From the known and the unknown
Thomas Scholzen,Johannes Gerdes +1 more
TL;DR: Although the Ki‐67 protein is well characterized on the molecular level and extensively used as a proliferation marker, the functional significance still remains unclear; there are indications, however, that Ki‐ 67 protein expression is an absolute requirement for progression through the cell‐division cycle.
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Ki-67 protein is associated with ribosomal RNA transcription in quiescent and proliferating cells.
Jörn Bullwinkel,Bettina Baron-Lühr,Anja Lüdemann,Claudia Wohlenberg,Johannes Gerdes,Thomas Scholzen +5 more
TL;DR: It is shown, that despite the strong downregulation of pKi‐67 expression in non‐proliferating cells, the protein can nevertheless be detected at sites linked to ribosomal RNA (rRNA) synthesis.
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Schistosome-derived omega-1 drives Th2 polarization by suppressing protein synthesis following internalization by the mannose receptor
Bart Everts,Leonie Hussaarts,Nicole N. Driessen,Moniek H.J. Meevissen,Gabriele Schramm,Alwin J. van der Ham,Barbara van der Hoeven,Thomas Scholzen,Sven Burgdorf,Sven Burgdorf,Markus Mohrs,Edward J. Pearce,Cornelis H. Hokke,Helmut L. Haas,Hermelijn H. Smits,Maria Yazdanbakhsh +15 more
TL;DR: Schistosome ribonuclease Omega-1 primes DCs to generate Th2 responses by binding and internalization by the mannose receptor and by subsequently impairing protein synthesis.
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Decreased differentiation of erythroid cells exacerbates ineffective erythropoiesis in β-thalassemia
Ilaria Libani,Ilaria Libani,Ella Guy,Luca Melchiori,Raffaella Schiro,Pedro Ramos,Pedro Ramos,Laura Breda,Thomas Scholzen,Amy Chadburn,Yifang Liu,Margrit Kernbach,Bettina Baron-Lühr,Matteo Porotto,Maria de Sousa,Eliezer A. Rachmilewitz,John Hood,M. Domenica Cappellini,Patricia J. Giardina,Robert W. Grady,Johannes Gerdes,Stefano Rivella +21 more
TL;DR: It is proposed that expansion of the erythroid pool followed by limited cell differentiation exacerbates IE in thalassemia and use of Jak2 inhibitors has the potential to profoundly change the management of this disorder.
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Chromophore-assisted light inactivation of pKi-67 leads to inhibition of ribosomal RNA synthesis.
TL;DR: It is argued for a crucial role of pKi‐67 in RNA polymerase I‐dependent nucleolar rRNA synthesis in the early steps of ribosomal RNA (rRNA) synthesis.