Ricardo A. Margni

TL;DR: It was observed that progesterone substitution abrogated the abortogenic effects of stress exposure by decreasing the frequency of abortogenic cytokines, which was exceedingly CD8-dependent, because depletion of CD8 led to a termination of the pregnancy protective effect of progester one substitution.

TL;DR: Characterization of CD11c+ cell kinetics in uterus and blood reveals variation of phenotype during pregnancy, pointing toward an eminent immunoregulatory role of DCs throughout gestation at the feto-maternal interface.

TL;DR: The hypothesis that ICAM-1/LFA-1 pathways may be involved in pregnancy rejection in murine models is tested and blocked, showing that fetal immune acceptance is restored in challenged pregnancies and mechanisms of fetal tolerance, e.g., indoleamine 2,3-dioxygenase expression, presence of CD4+CD25bright regulatory T cells, and synthesis of asymmetric Abs, are ICAM/L FA-1 dependent.

TL;DR: Results suggest a protective role of AAb during pregnancy and the proportion of asymmetric IgG molecules in serum samples of healthy pregnant and non‐pregnant women and pregnant women with a history of RSA patients receiving paternal lymphocyte immunotherapy or intravenous gammaglobulin therapy.

TL;DR: IL-6 produced not only by immunocompetent cells such as macrophages and mast cells, but also by trophoblasts and decidua cells, is directly involved in the pathology of abortion.