Sandra M. Blois

TL;DR: It is shown that galectin-1 (Gal-1), an immunoregulatory glycan-binding protein, has a pivotal role in conferring fetomaternal tolerance and is a pivotal regulator of fetom maternal tolerance that has potential therapeutic implications in threatened pregnancies.

TL;DR: The identification of risk factors for miscarriage during the first trimester in women with no obvious risk for a pregnancy loss and development of an interaction model of these factors will help clinicians to recognize pregnant women who require extra monitoring and who might benefit from therapeutic interventions such as progestogen supplementation, especially during thefirst weeks of pregnancy, to prevent a miscarriage.

TL;DR: It was observed that progesterone substitution abrogated the abortogenic effects of stress exposure by decreasing the frequency of abortogenic cytokines, which was exceedingly CD8-dependent, because depletion of CD8 led to a termination of the pregnancy protective effect of progester one substitution.

TL;DR: Characterization of CD11c+ cell kinetics in uterus and blood reveals variation of phenotype during pregnancy, pointing toward an eminent immunoregulatory role of DCs throughout gestation at the feto-maternal interface.

TL;DR: Current evidence on the regulatory pathways driving decidualization in mice is discussed, suggesting that NK cells promote uterine vascular modifications that assist decidUAL growth but DC directly control stromal cell proliferation, angiogenesis and the homing and maturation of NK cell precursors in the pregnant uterus.