Ricardo Riguera

TL;DR: In this paper, the application of (S)-1,10-binaphthyl-2,20-diol as NMR chiral solvating agent (CSA) for omeprazole, and three of its analogs (lanso-, panto-, and rabe-prazole) was investigated.

TL;DR: Findings indicate that this novel targeted nanoparticulate drug delivery system was able to translocate into the brain tissue after iv administration, and these novel nanoparticles are promising carriers for the transport of the anticaspase peptide Z-DEVD-FMK into thebrain.

TL;DR: Key aspects found in the development of the efficient and benign functionalization of biomacromolecules through CuAAC, as well as the Cu-free strain-promoted azide-alkyne cycloaddition (SPAAC) are discussed.

TL;DR: A practical guide for the assignment of the absolute configuration of alcohols, amines and carboxylic acids by NMR is presented in this article, which includes information required for the judicious selection of the most suitable auxiliary reagent (MPA, MTPA, BPG, 9-AMA and 9-AHA), derivatization procedures and NMR conditions for each substrate, as well as a critical account on the reliability, scope and limitations of these applications.

TL;DR: Click chemistry in combination with ultrafiltration has allowed the quick, efficient, and reliable multivalent conjugation of unprotected alkyne-derived carbohydrates to three generations of azido-terminated gallic acid−triethylene glycol dendrimers under aqueous conditions.