https://pubs.rsc.org/en/content/articlepdf/2019/NP/C8NP00092A

Marine natural products.

PLGA-based nanoparticles: An overview of biomedical applications

/pdf/nanoparticle-pegylation-for-imaging-and-therapy-45vkc0dds0.pdf

Nanoparticle PEGylation for imaging and therapy

Polysaccharides-based nanoparticles as drug delivery systems

Polymeric materials have been used in a range of pharmaceutical and biotechnology products for more than 40 years. These materials have evolved from their earlier use as biodegradable products such as resorbable sutures, orthopaedic implants, macroscale and microscale drug delivery systems such as microparticles and wafers used as controlled drug release depots, to multifunctional nanoparticles (NPs) capable of targeting, and controlled release of therapeutic and diagnostic agents. These newer generations of targeted and controlled release polymeric NPs are now engineered to navigate the complex in vivo environment, and incorporate functionalities for achieving target specificity, control of drug concentration and exposure kinetics at the tissue, cell, and subcellular levels. Indeed this optimization of drug pharmacology as aided by careful design of multifunctional NPs can lead to improved drug safety and efficacy, and may be complimentary to drug enhancements that are traditionally achieved by medicinal chemistry. In this regard, polymeric NPs have the potential to result in a highly differentiated new class of therapeutics, distinct from the original active drugs used in their composition, and distinct from first generation NPs that largely facilitated drug formulation. A greater flexibility in the design of drug molecules themselves may also be facilitated following their incorporation into NPs, as drug properties (solubility, metabolism, plasma binding, biodistribution, target tissue accumulation) will no longer be constrained to the same extent by drug chemical composition, but also become in-part the function of the physicochemical properties of the NP. The combination of optimally designed drugs with optimally engineered polymeric NPs opens up the possibility of improved clinical outcomes that may not be achievable with the administration of drugs in their conventional form. In this critical review, we aim to provide insights into the design and development of targeted polymeric NPs and to highlight the challenges associated with the engineering of this novel class of therapeutics, including considerations of NP design optimization, development and biophysicochemical properties. Additionally, we highlight some recent examples from the literature, which demonstrate current trends and novel concepts in both the design and utility of targeted polymeric NPs (444 references).

/pdf/targeted-polymeric-therapeutic-nanoparticles-design-pj01q1y8xh.pdf

Targeted polymeric therapeutic nanoparticles: design, development and clinical translation

The application of (S)-1,10-binaphthyl-2,20-diol as NMR chiral solvating agent (CSA) for omeprazole, and three of its analogs (lanso-, panto-, and rabe-prazole) was investigated. The formation of diastereomeric host–guest complexes in solution between the CSA and the racemic substrates produced sufficient NMR signal splitting for the determination of enantiomeric excesses by Hor F-NMR spectroscopy. Using of hydrophobic deuterated solvents was mandatory for obtaining good enantiodiscrimination, thus suggesting the importance of intermolecular hydrogen bonds in the stabilization of the complexes. The method was applied to the fast quantification of the enantiomeric purity of in-process samples of S-omeprazole. Chirality 00:000–000, 2009. VC 2009

The assignment of absolute configuration by NMR

Chitosan–PEG nanocapsules as new carriers for oral peptide delivery: Effect of chitosan pegylation degree

Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.

A practical guide for the assignment of the absolute configuration of alcohols, amines and carboxylic acids by NMR is presented. The guide includes information required for the judicious selection of the most suitable auxiliary reagent (MPA, MTPA, BPG, 9-AMA and 9-AHA), derivatization procedures and NMR conditions (solvent and temperature) for each substrate, as well as a critical account on the reliability, scope and limitations of these applications.

Emilio Quiñoá

Papers

The assignment of absolute configuration by NMR

Chitosan–PEG nanocapsules as new carriers for oral peptide delivery: Effect of chitosan pegylation degree

Development and brain delivery of chitosan-PEG nanoparticles functionalized with the monoclonal antibody OX26.

A practical guide for the assignment of the absolute configuration of alcohols, amines and carboxylic acids by NMR

Supramolecular Assemblies from Poly(phenylacetylene)s