R
Ricardo Villa-Bellosta
Researcher at Autonomous University of Madrid
Publications - 35
Citations - 944
Ricardo Villa-Bellosta is an academic researcher from Autonomous University of Madrid. The author has contributed to research in topics: Calcification & Pyrophosphate. The author has an hindex of 13, co-authored 35 publications receiving 702 citations. Previous affiliations of Ricardo Villa-Bellosta include Centro Nacional de Investigaciones Cardiovasculares.
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Journal ArticleDOI
Defective Extracellular Pyrophosphate Metabolism Promotes Vascular Calcification in a Mouse Model of Hutchinson-Gilford Progeria Syndrome That Is Ameliorated on Pyrophosphate Treatment
Ricardo Villa-Bellosta,José Rivera-Torres,Fernando G. Osorio,Rebeca Acín-Pérez,José Antonio Enríquez,Carlos López-Otín,Vicente Andrés +6 more
TL;DR: Findings reveal a previously undefined pathogenic process in HGPS that may also contribute to vascular calcification in normal aging, because progerin progressively accumulates in the vascular tissue of individuals without HGPS.
Journal ArticleDOI
Miro-1 links mitochondria and microtubule Dynein motors to control lymphocyte migration and polarity.
Giulia Morlino,Olga Barreiro,Francesc Baixauli,Javier Robles-Valero,José María González-Granado,Ricardo Villa-Bellosta,J. Cuenca,Carlos Oscar Sánchez-Sorzano,Esteban Veiga,Noa B. Martín-Cófreces,Francisco Sánchez-Madrid +10 more
TL;DR: It is shown that during adhesion to the activated endothelium under physiological flow conditions, lymphocyte mitochondria redistribute to the adhesion zone together with the microtubule-organizing center (MTOC) in an integrin-dependent manner.
Journal ArticleDOI
Vascular Smooth Muscle-Specific Progerin Expression Accelerates Atherosclerosis and Death in a Mouse Model of Hutchinson-Gilford Progeria Syndrome
Magda R. Hamczyk,Ricardo Villa-Bellosta,Pilar Gonzalo,María J. Andrés-Manzano,Paula Nogales,Jacob F. Bentzon,Jacob F. Bentzon,Carlos López-Otín,Vicente Andrés +8 more
TL;DR: It is demonstrated that restricting progerin expression to VSMCs is sufficient to accelerate atherosclerosis, trigger plaque vulnerability, and reduce lifespan, and the results identify proger in-induced VSMC death as a major factor triggering atheros sclerosis and premature death in HGPS.
Journal ArticleDOI
Progerin accelerates atherosclerosis by inducing endoplasmic reticulum stress in vascular smooth muscle cells.
Magda R. Hamczyk,Magda R. Hamczyk,Ricardo Villa-Bellosta,Víctor Quesada,Pilar Gonzalo,Sandra Vidak,Rosa M Nevado,María J. Andrés-Manzano,Tom Misteli,Carlos López-Otín,Vicente Andrés +10 more
TL;DR: Endoplasmic reticulum stress (ER) and the unfolded protein responses as drivers of VSMC death in two mouse models of HGPS exhibiting ubiquitous and VSMC‐specific progerin expression are identified.
Journal ArticleDOI
Phosphate, pyrophosphate, and vascular calcification: a question of balance.
TL;DR: Vascular calcification, the pathological calcification of cardiovascular structures, is one of the most important factors determining patients' mortality around the world and in recent years, some risk factors are emerging, including elevated serum phosphorus and defective synthesis of pyrophosphate.