R
Richard A. Proctor
Researcher at University of Wisconsin-Madison
Publications - 203
Citations - 14978
Richard A. Proctor is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Staphylococcus aureus & Mutant. The author has an hindex of 70, co-authored 190 publications receiving 14052 citations. Previous affiliations of Richard A. Proctor include Merck & Co. & University of Geneva.
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Small colony variants: a pathogenic form of bacteria that facilitates persistent and recurrent infections
Richard A. Proctor,Christof von Eiff,Barbara C. Kahl,Karsten Becker,Peter J. McNamara,Mathias Herrmann,Georg Peters +6 more
TL;DR: This Review covers the phenotypic, genetic and clinical picture associated with small colony variants, with an emphasis on staphylococci, for which the greatest amount of information is available.
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Persistent and Relapsing Infections Associated with Small-Colony Variants of Staphylococcus aureus
TL;DR: A model relating the phenotypic characteristics of S. aureus SCVs with the clinical pattern of persistent and relapsing infection is proposed.
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Staphylococcus aureus Panton-Valentine Leukocidin Is a Very Potent Cytotoxic Factor for Human Neutrophils
Bettina Löffler,Muzaffar Hussain,Matthias Grundmeier,Michaela Brück,Dirk Holzinger,Georg Varga,Johannes Roth,Barbara C. Kahl,Richard A. Proctor,Georg Peters +9 more
TL;DR: The results question the value of infection-models in mice and non-human primates to elucidate the impact of PVL and suggest that PVL has an important cytotoxic role in human neutrophils, which has major implications for the pathogenesis of CA-MRSA infections.
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Staphylococcus aureus phenotype switching: an effective bacterial strategy to escape host immune response and establish a chronic infection
Lorena Tuchscherr,Eva Medina,Muzaffar Hussain,Wolfgang Völker,Vanessa Heitmann,Silke Niemann,Dirk Holzinger,Johannes Roth,Richard A. Proctor,Karsten Becker,Georg Peters,Bettina Löffler +11 more
TL;DR: It is demonstrated that viable bacteria can persist within host cells and/or tissues for several weeks and bacterial phenotype switching is an integral part of the infection process that enables the bacteria to hide inside host cells, which can be a reservoir for chronic and therapy‐refractive infections.
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At the Crossroads of Bacterial Metabolism and Virulence Factor Synthesis in Staphylococci
TL;DR: This review uses information derived primarily using Bacillus subtilis and Escherichia coli to articulate how gram-positive pathogens, with emphasis on Staphylococcus aureus and Staphyllococcus epidermidis, regulate virulence determinant expression in response to a changing environment.