J
Johannes Roth
Researcher at University of Münster
Publications - 427
Citations - 30004
Johannes Roth is an academic researcher from University of Münster. The author has contributed to research in topics: Inflammation & Arthritis. The author has an hindex of 89, co-authored 397 publications receiving 26440 citations. Previous affiliations of Johannes Roth include University of Duisburg-Essen & RWTH Aachen University.
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Journal ArticleDOI
Mrp8 and Mrp14 are endogenous activators of Toll-like receptor 4, promoting lethal, endotoxin-induced shock
Thomas Vogl,Klaus Tenbrock,Stephan Ludwig,Nadja Leukert,Christina Ehrhardt,Marieke A. D. van Zoelen,Wolfgang Nacken,Dirk Foell,Tom van der Poll,Clemens Sorg,Johannes Roth +10 more
TL;DR: It is demonstrated that mice lacking Mrp8-Mrp14 complexes are protected from endotoxin-induced lethal shock and Escherichia coli–induced abdominal sepsis, indicating new inflammatory components that amplify phagocyte activation during sepsi upstream of TNFα–dependent effects.
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Inhibition of dendritic cell differentiation and accumulation of myeloid-derived suppressor cells in cancer is regulated by S100A9 protein
Pingyan Cheng,Cesar A. Corzo,Noreen Luetteke,Bin Yu,Srinivas Nagaraj,Marylin M. Bui,Myrna L. Ortiz,Wolfgang Nacken,Clemens Sorg,Thomas Vogl,Johannes Roth,Dmitry I. Gabrilovich +11 more
TL;DR: It is reported here that STAT3-inducible up-regulation of the myeloid-related protein S100A9 enhances MDSC production in cancer and reveals a novel molecular mechanism of immunological abnormalities in cancer.
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S100 proteins expressed in phagocytes: a novel group of damage-associated molecular pattern molecules
TL;DR: Analyzing the molecular basis of the specific effects exhibited by S100 proteins in greater detail bears the potential to elucidate important mechanisms of innate immunity, to establish valid biomarkers of phagocytic inflammation, and eventually to reveal novel targets for innovative anti‐inflammatory therapies.
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The endogenous Toll-like receptor 4 agonist S100A8/S100A9 (calprotectin) as innate amplifier of infection, autoimmunity, and cancer
TL;DR: S 100A8/S100A9 is not only involved in promoting the inflammatory response in infections but was also identified as a potent amplifier of inflammation in autoimmunity as well as in cancer development and tumor spread.
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Myeloid-related protein (MRP) 8 and MRP14, calcium-binding proteins of the S100 family, are secreted by activated monocytes via a novel, tubulin-dependent pathway.
TL;DR: The data provide evidence that the S100 proteins MRP8 and MRP14 are secreted after activation of protein kinase C via a novel pathway requiring an intact microtubule network and is associated with down-regulation of their de novo synthesis.