R
Richard A. Wells
Researcher at Sunnybrook Health Sciences Centre
Publications - 11
Citations - 137
Richard A. Wells is an academic researcher from Sunnybrook Health Sciences Centre. The author has contributed to research in topics: Haematopoiesis & Bone marrow. The author has an hindex of 5, co-authored 11 publications receiving 106 citations. Previous affiliations of Richard A. Wells include Sunnybrook Research Institute & University of Toronto.
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Journal ArticleDOI
Cross-Talk between PPARs and the Partners of RXR: A Molecular Perspective.
TL;DR: Cross-talk through DNA binding and RXR heterodimerization present challenges to the study of these nuclear receptors that cannot be adequately addressed by current experimental approaches.
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Iron Overload and Haematopoiesis in MDS: Does Blood Transfusion Promote Progression to AML?
Lap Shu Alan Chan,Rena Buckstein,Marciano D. Reis,Alden Chesney,Adam Lam,Matthew C. Cheung,Eugenia Piliotis,Lilly Chunhong Gu,Richard A. Wells +8 more
TL;DR: These results establish a relationship between CD34+ cell ROS content and serum ferritin concentration in MDS patients with iron overload, and indicate that iron chelation therapy in this patient population reverses this ROS accumulation.
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Evidence of functional interaction between NuMA-RARα and RXRα in an in vivo model of acute promyelocytic leukemia
Mahadeo A. Sukhai,Mahadeo A. Sukhai,Mariam Thomas,Mariam Thomas,Yali Xuan,Lap Shu Alan Chan,Lap Shu Alan Chan,Soheila A. Hamadanizadeh,Soheila A. Hamadanizadeh,Tong Zhang,Rikki R. Bharadwaj,Andre C. Schuh,Andre C. Schuh,Richard A. Wells,Richard A. Wells,Suzanne Kamel-Reid +15 more
TL;DR: It is proposed that the APL fusion protein NuMA-RARα cooperates with RXRα in the development of leukemia in hCG-NuMA- RARα transgenic mice and suggest a novel role for RXR α in the pathogenesis of APL.
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Iron Overload Accelerates Development of Leukaemia: Evidence From a Mouse Model
TL;DR: It is hypothesized that iron, via increased iROS, promotes accumulation of DNA damage in MDS HSCs and thus, in the context of the genomic instability of the MDS clone, accelerates progression of MDS to AML and the biological and mechanistic plausibility of this hypothesis is established.
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Intracellular ROS profile in hematopoietic progenitors of MDS patients: association with blast count and iron overload
TL;DR: The siROS profile in early hematopoietic cells of MDS patients is established and its relationship with blast count and iron overload is established.