A
Andre C. Schuh
Researcher at University of Toronto
Publications - 86
Citations - 2758
Andre C. Schuh is an academic researcher from University of Toronto. The author has contributed to research in topics: Myeloid leukemia & Leukemia. The author has an hindex of 23, co-authored 86 publications receiving 2596 citations. Previous affiliations of Andre C. Schuh include Ontario Institute for Cancer Research & Princess Margaret Cancer Centre.
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Journal ArticleDOI
Corrigendum: Identification of pre-leukaemic haematopoietic stem cells in acute leukaemia
Liran I. Shlush,Sasan Zandi,Amanda Mitchell,Weihsu Claire Chen,Joseph Brandwein,Vikas Gupta,James A. Kennedy,Aaron D. Schimmer,Andre C. Schuh,Karen W.L. Yee,Jessica McLeod,Monica Doedens,Jessie J. F. Medeiros,Rene Marke,Hyeoung Joon Kim,Kwon Lee,John Douglas Mcpherson,Thomas J. Hudson,Andrew M.K. Brown,Fouad Yousif,Quang M. Trinh,Lincoln Stein,Mark D. Minden,Jean C.Y. Wang,John E. Dick +24 more
TL;DR: This corrects the article to show that the method used to derive the H2O2 “spatially aggregating force” is based on a two-step process, not a single step, called a “shots fired” process.
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In vitro hematopoietic and endothelial potential of flk-1−/− embryonic stem cells and embryos
TL;DR: It is shown that flk-1(-/-) embryonic stem cells are nevertheless able to differentiate into hematopoietic and endothelial cells in vitro, although they give rise to a greatly reduced number of blast colonies, a measure of hemangioblast potential.
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A phase I study of the pan bcl-2 family inhibitor obatoclax mesylate in patients with advanced hematologic malignancies.
Aaron D. Schimmer,Susan O'Brien,Hagop M. Kantarjian,Joseph Brandwein,Bruce D. Cheson,Mark D. Minden,Karen W.L. Yee,Farhad Ravandi,Francis J. Giles,Andre C. Schuh,Vikas Gupta,Michael Andreeff,Charles Koller,Hong Chang,Suzanne Kamel-Reid,Mark S. Berger,Jean Viallet,Gautam Borthakur +17 more
TL;DR: The small-molecule pan-Bcl-2 inhibitor obatoclax mesylate is well tolerated and these results support its further investigation in patients with leukemia and myelodysplasia.
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Three differentially expressed survivin cDNA variants encode proteins with distinct antiapoptotic functions
Edward M. Conway,Saskia Pollefeyt,Saskia Pollefeyt,Jan Cornelissen,Jan Cornelissen,Inky DeBaere,Inky DeBaere,Marta Steiner-Mosonyi,Marta Steiner-Mosonyi,Kelly Ong,Kelly Ong,Mathijs Baens,Mathijs Baens,Desiré Collen,Desiré Collen,Andre C. Schuh,Andre C. Schuh +16 more
TL;DR: The presence of distinct isoforms of survivin that are expressed differentially suggests that survivin plays a complex role in regulating apoptosis.
Journal ArticleDOI
Cell surface antigen CD109 is a novel member of the α2 macroglobulin/C3, C4, C5 family of thioester-containing proteins
Martin Lin,D. Robert Sutherland,Wendy Horsfall,Nicholas F. Totty,Erik Yeo,Rakash Nayar,Xiang-Fu Wu,Andre C. Schuh +7 more
TL;DR: Not only is CD109 potentially capable of covalent binding to carbohydrate and protein targets, but the t(1/2) of its activated thioester is likely extremely short, indicating that CD109 action is highly restricted spatially to the site of its activation.