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Richard B. Sykes
Researcher at Princeton University
Publications - 82
Citations - 4578
Richard B. Sykes is an academic researcher from Princeton University. The author has contributed to research in topics: Lactam & Monobactam. The author has an hindex of 33, co-authored 82 publications receiving 4478 citations. Previous affiliations of Richard B. Sykes include University of Bristol & Papworth Hospital.
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Book ChapterDOI
The β-Lactamases of Gram-Negative Bacteria and their Possible Physiological Role
M H Richmond,Richard B. Sykes +1 more
TL;DR: There is complexity in breakdown of the cephalosporins after β -lactamase action as there is no sporin and the formation of any single product—a fact that invalidates the iodometric assay of cep Halosporinase for absolute measurement.
Journal ArticleDOI
Properties of an R Factor from Pseudomonas aeruginosa
TL;DR: The R factor was transferable from E. coli to bacterial genera outside the Enterobacteriaceae (Pseudomonas and members of the Rhizobiaceae) to which transfer of F-like and I-like plasmids could not be demonstrated.
Journal ArticleDOI
Azthreonam (SQ 26,776), a synthetic monobactam specifically active against aerobic gram-negative bacteria.
TL;DR: Azthreonam protected mice against experimental infections produced by a range of gram-negative bacteria, exhibiting efficacy comparable to that of cefotaxime and ceftazidime.
Journal ArticleDOI
Monocyclic beta-lactam antibiotics produced by bacteria.
Richard B. Sykes,Christopher M. Cimarusti,D. P. Bonner,Karen Bush,David M. Floyd,Nafsika H. Georgopapadakou,W. H. Koster,Wen-Chih Liu,William L. Parker,Pacifico A. Principe,Marlene L. Rathnum,William A. Slusarchyk,W. H. Trejo,Wells Jerry S +13 more
TL;DR: From over one million bacterial isolates screened, this work has identified seven related molecules containing β-lactams produced by a range of bacterial species, and suggests the class name ‘monobactam’.
Journal ArticleDOI
Properties of RP4, an R Factor Which Originated in Pseudomonas aeruginosa S8
TL;DR: RP1, a group of genes specifying resistance to carbenicillin, neomycin, kanamycin, and tetracycline and originating in a strain of Pseudomonas aeruginosa, was freely transmissible between strains of P. aerug inosa, Escherichia coli, and Proteus mirabilis.