K
Karen Bush
Researcher at Indiana University
Publications - 231
Citations - 26553
Karen Bush is an academic researcher from Indiana University. The author has contributed to research in topics: Antibacterial agent & Ceftazidime. The author has an hindex of 70, co-authored 229 publications receiving 24091 citations. Previous affiliations of Karen Bush include Johnson & Johnson & Kosan Biosciences.
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Journal ArticleDOI
A functional classification scheme for beta-lactamases and its correlation with molecular structure.
TL;DR: These enzymes are the major cause of bacterial resistance to b-lactam antibiotics and have been the subject of extensive microbiological, biochemical, and genetic investigations.
Journal ArticleDOI
Carbapenemases: the versatile beta-lactamases.
Anne Marie Queenan,Karen Bush +1 more
TL;DR: The characteristics, epidemiology, and detection of the carbapenemases found in pathogenic bacteria are updates and metallo-β-lactamases are detected primarily in Pseudomonas aeruginosa.
Journal ArticleDOI
Updated Functional Classification of β-Lactamases
Karen Bush,George A. Jacoby +1 more
TL;DR: The functional classification scheme updated herein is based on the 1995 proposal and includes group 1 (class C) cephalosporinases; group 2 (classes A and D) broad-spectrum, inhibitor-resistant, and extended-spectrums β-lactamases and serine carbapenemases; and group 3 metallo-β-lacticamases.
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Novel Carbapenem-Hydrolyzing β-Lactamase, KPC-1, from a Carbapenem-Resistant Strain of Klebsiella pneumoniae
Hesna Yigit,Anne Marie Queenan,Gregory J. Anderson,Antonio Doménech-Sánchez,James W. Biddle,Christine D. Steward,Sebastián Albertí,Karen Bush,Fred C. Tenover +8 more
TL;DR: K. pneumoniae strain 1534 is mainly due to production of a novel Bush group 2f, class A, carbapenem-hydrolyzing β-lactamase, KPC-1, although alterations in porin expression may also play a role.
Journal ArticleDOI
Tackling antibiotic resistance
Karen Bush,Patrice Courvalin,Gautam Dantas,Julian Davies,Barry I. Eisenstein,Pentti Huovinen,George A. Jacoby,Roy Kishony,Barry N. Kreiswirth,Elizabeth Kutter,Stephen A. Lerner,Stuart B. Levy,Kim Lewis,Olga Lomovskaya,Jeffrey H Miller,Shahriar Mobashery,Laura J. V. Piddock,Steven J. Projan,Christopher M. Thomas,Alexander Tomasz,Paul M. Tulkens,Timothy R. Walsh,James D. Watson,Jan A. Witkowski,Wolfgang Witte,Gerry Wright,Pamela J. Yeh,Helen I. Zgurskaya +27 more
TL;DR: To explore how the problem of antibiotic resistance might best be addressed, a group of 30 scientists from academia and industry gathered at the Banbury Conference Centre in Cold Spring Harbor, New York, USA, from 16 to 18 May 2011.