Richard D. Hoge

TL;DR: The usefulness of intrasubject registration for post hoc MR signal averaging for in vivo human neuroanatomy was investigated and the enhanced signal in the averaged images resulted in higher quality anatomical images, which lent themselves to several postprocessing techniques.

TL;DR: This study has preformed simultaneous near-infrared spectroscopy (NIRS) along with BOLD and ASL (arterial spin labeling)-based fMRI during an event-related motor activity in human subjects in order to compare the temporal dynamics of the hemodynamic responses recorded in each method.

TL;DR: By reducing the signal strength using higher image resolution, the ratio of physiologic to image noise could be reduced to a regime where increased sensitivity afforded by higher field strength still translated to improved SNR in the fMRI time-series.

TL;DR: A quantitative model, based on flow‐dependent dilution of metabolically generated deoxyhemoglobin, was validated by measuring BOLD signals and relative CBF simultaneously in the primary visual cortex of human subjects during graded hypercapnia at different levels of visual stimulation and yielded MRI‐based CMRO2 measurements that were in agreement with PET results for equivalent stimuli.

TL;DR: Estimation of aerobic ATP yields from the observed CMR(O(2)) increases and comparison with the maximum possible anaerobic ATP contribution indicate that elevated energy demands during brain activation are met largely through oxidative metabolism.