Richard D. Miller

TL;DR: A protocol for the small-volume continuous preparation of multi-kilogram quantities of a cancer drug candidate, prexasertib monolactate monohydrate, under current good manufacturing practices is reported, which afforded improved performance and safety relative to batch processes and also improved containment of a highly potent compound.

TL;DR: Key mechanistic insights include the observation of electron donor-acceptor complexes in solution as well as a high dependence on photon flux have culminated in the application of this chemistry on a kilogram scale, demonstrating the utility of this reagent combination for preparative applications.

TL;DR: Two different continuous flow approaches to a key 1H-4-substituted imidazole intermediate are reported, highlighting the rapid development of chemistry in research-scale PFRs and speed to material delivery through linear scale up to a pilot- scale PFR under GMP conditions.

TL;DR: In this paper, the development and scale-up of a synthetic route to tasisulam sodium (5-bromo-thiophene-2-sulfonic acid 2,4-dichlorobenzoylamide sodium salt) utilizing continuous Schotten-Baumann reaction conditions is disclosed.

TL;DR: Development of a small volume continuous process that used a combination of batch and flow unit operations to manufacture the small molecule oncolytic candidate merestinib is described.