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Richard D. Palmiter
Researcher at University of Washington
Publications - 455
Citations - 74646
Richard D. Palmiter is an academic researcher from University of Washington. The author has contributed to research in topics: Dopamine & Gene. The author has an hindex of 141, co-authored 444 publications receiving 69977 citations. Previous affiliations of Richard D. Palmiter include University of Pennsylvania & Howard Hughes Medical Institute.
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Journal ArticleDOI
Dopamine-dependent desensitization of dopaminergic signaling in the developing mouse striatum.
TL;DR: The results suggest that striatal dopamine receptors are capable of transducing extracellular signals at P4 and P6, but dopaminergic neurotransmission begins thereafter, and Dopaminoceptive neurons appear to reduce their sensitivity to dopamine as dopamine terminals innervate the striatum and functional neurotransmission begin.
Book ChapterDOI
Examining Adrenergic Roles in Development, Physiology, and Behavior through Targeted Disruption of the Mouse Dopamine β-Hydroxylase Gene
TL;DR: A novel approach to studying the adrenergic nervous system by genetically altering mice without allowing them to produce norepinephrine and epinephrine was accomplished by targeted disruption of the dopamine β -hydroxylase (DBH) gene.
Journal ArticleDOI
Germ-line intrachromosomal recombination restores fertility in transgenic MyK-103 male mice.
TL;DR: Clins of germ cells that fail to express HSV thymidine kinase arose by transgene deletion in embryonic germ cells and postnatal spermatogonial stem cells and are responsible for the normal fertility of MyK-103 males, and the frequency of recombination events at the integration locus suggests that it contains a hotspot for mitotic recombination.
Journal ArticleDOI
Heparin-binding correlates with increased efficiency of AAV1- and AAV6-mediated transduction of striated muscle, but negatively impacts CNS transduction.
Andrea L. Arnett,Lisa R. Beutler,Albert Quintana,James M. Allen,Eric E. Finn,Richard D. Palmiter,Jeffrey S. Chamberlain +6 more
TL;DR: Heparin-binding capability is an important determinant of transduction that should be considered in the design of rAAV-mediated gene therapies, and the transduction profile of these vectors in vivo across multiple routes of administration is evaluated.
Journal ArticleDOI
Genetic comparison of seizure control by norepinephrine and neuropeptide Y.
David Weinshenker,Patricia Szot,Nicole S. Miller,Nicole C. Rust,John G. Hohmann,Ujwal Pyati,Sylvia S. White,Richard D. Palmiter +7 more
TL;DR: Data suggest that NE is a more potent endogenous anticonvulsant than NPY, and that NPY has the greatest contribution under conditions of extreme neuronal excitability.