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Richard I. Whyte
Researcher at Beth Israel Deaconess Medical Center
Publications - 136
Citations - 8831
Richard I. Whyte is an academic researcher from Beth Israel Deaconess Medical Center. The author has contributed to research in topics: Lung cancer & Lung transplantation. The author has an hindex of 38, co-authored 132 publications receiving 8446 citations. Previous affiliations of Richard I. Whyte include Stanford University & Medical University of South Carolina.
Papers
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Journal ArticleDOI
Diversity of gene expression in adenocarcinoma of the lung
Mitchell E. Garber,Olga G. Troyanskaya,Karsten Schluens,Simone Petersen,Zsuzsanna Thaesler,Manuela Pacyna-Gengelbach,Matt van de Rijn,Glenn D. Rosen,Charles M. Perou,Richard I. Whyte,Russ B. Altman,Patrick O. Brown,David Botstein,Iver Petersen +13 more
TL;DR: Gene expression analysis promises to extend and refine standard pathologic analysis and make possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival.
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Thin-section CT obtained at 10-mm increments versus limited three-level thin-section CT for idiopathic pulmonary fibrosis: correlation with pathologic scoring.
Ella A. Kazerooni,Fernando J. Martinez,Andrew Flint,David A. Jamadar,Barry H. Gross,D L Spizarny,Philip N. Cascade,Richard I. Whyte,J P Lynch rd,Galen B. Toews +9 more
TL;DR: Limited thin-section CT reveals the pathologic changes associated with IPF as well as CT obtained at 10-mm increments as an added advantage of limited thin- section CT is that it exposes patients to less radiation.
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Idiopathic pulmonary fibrosis: predicting response to therapy and survival.
Ella A. Kazerooni,Galen B. Toews,J P Lynch rd,Barry H. Gross,Philip N. Cascade,D L Spizarny,Andrew Flint,M A Schork,Richard I. Whyte,John Popovich,Robert C. Hyzy,Fernando J. Martinez +11 more
TL;DR: It is demonstrated that pretherapy pulmonary function, pathologic and radiographic parameters are different in individuals who respond to initial prednisone therapy and only HRCT imaging and pathologic fibrosis were able to reliably predict long-term survival in patients with biopsy-proven IPF.
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Interferon-gamma-inducible protein 10 (IP-10) is an angiostatic factor that inhibits human non-small cell lung cancer (NSCLC) tumorigenesis and spontaneous metastases.
Douglas A. Arenberg,Steven L. Kunkel,Peter J. Polverini,Susan B. Morris,Marie D. Burdick,Mary C. Glass,Dennis T. Taub,Mark D. Iannettoni,Richard I. Whyte,Robert M. Strieter +9 more
TL;DR: The notion that tumor-derived IP-10 is an important endogenous angiostatic factor in NSCLC is supported, as a potent angiOSTatic factor that regulates non-small cell lung cancer-derived angiogenesis, tumor growth, and spontaneous metastasis.
Journal ArticleDOI
Inhibition of interleukin 8 attenuates angiogenesis in bronchogenic carcinoma.
Daniel R. Smith,Peter J. Polverini,Steven L. Kunkel,Mark B. Orringer,Richard I. Whyte,Marie D. Burdick,Carol A. Wilke,Robert M. Strieter +7 more
TL;DR: These observations definitively establish IL-8 as a primary mediator of angiogenesis in bronchogenic carcinoma and offer a potential target for immunotherapies against solid malignancies.