Simone Petersen

TL;DR: Gene expression analysis promises to extend and refine standard pathologic analysis and make possible the subclassification of adenocarcinoma into subgroups that correlated with the degree of tumor differentiation as well as patient survival.

TL;DR: The study strengthens the notion that different tumor subgroups of the respiratory tract are characterized by distinct patterns of chromosomal alterations.

TL;DR: Comparative genomic hybridization was applied to squamous cellcarcinomas of the lung to define chromosomal imbalances that are associated with the metastatic phenotype, and metastasis-associated lesions were frequently detectable in the primary tumour providing a method of identifying patients at risk for tumour dissemination.

TL;DR: The genomic data being derived from the evaluation of primary HNSCC enabled a stratification of the patients into subgroups with different survival highlighting the necessity of a genetically based tumor classification for refining diagnosis and treatment of H NSCC patients.

TL;DR: The analysis of the paired samples revealed considerable chromosomal instability, but indicated a clonal relationship in each case, suggesting that loss of function mutations are critical in the initial phase of tumour dissemination, whereas the metastases preferentially acquired DNA gains, probably modulating the metastatic phenotype.