R
Richard L. Klein
Researcher at Medical University of South Carolina
Publications - 100
Citations - 5994
Richard L. Klein is an academic researcher from Medical University of South Carolina. The author has contributed to research in topics: Diabetes mellitus & Lipoprotein. The author has an hindex of 38, co-authored 98 publications receiving 5495 citations. Previous affiliations of Richard L. Klein include United States Department of Veterans Affairs & Veterans Health Administration.
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Journal ArticleDOI
Adiponectin promotes adipocyte differentiation, insulin sensitivity, and lipid accumulation.
TL;DR: A new role is suggested for adiponectin as an autocrine factor in adipose tissues: promoting cell proliferation and differentiation from preadipocytes into adipocytes, augmenting programmed gene expression responsible for adipogenesis, and increasing lipid content and insulin responsiveness of the glucose transport system in adipocytes.
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Effects of Insulin Resistance and Type 2 Diabetes on Lipoprotein Subclass Particle Size and Concentration Determined by Nuclear Magnetic Resonance
W. Timothy Garvey,Soonho Kwon,Deyi Zheng,Sara Shaughnessy,Penny Wallace,Amy Hutto,Kimberly Pugh,Alicia J. Jenkins,Richard L. Klein,Youlian Liao +9 more
TL;DR: It is concluded that insulin resistance had profound effects on lipoprotein size and subclass particle concentrations for VLDL, LDL, and HDL when measured by NMR; in type 2 diabetes, the lipop protein subclass alterations are moderately exacerbated but can be attributed primarily to the underlying insulin resistance.
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Adiponectin multimeric complexes and the metabolic syndrome trait cluster.
TL;DR: In this article, the authors examined the relationship between circulating levels of total adiponectin and the relative distribution of multimeric forms with key features of the metabolic syndrome and concluded that it is HMW quantity, not total or HMW-to-total adiponiectin ratio, that was primarily responsible for these relationships.
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Diabetic retinopathy and serum lipoprotein subclasses in the DCCT/EDIC cohort
Timothy J. Lyons,Alicia J. Jenkins,Deyi Zheng,Daniel T. Lackland,Daniel L. McGee,W. Timothy Garvey,W. Timothy Garvey,Richard L. Klein +7 more
TL;DR: The data are consistent with a role for dyslipoproteinemia involving lipoprotein subclasses in the pathogenesis of diabetic retinopathy, and NMR-LSP reveals new associations between serum lipoproteins and severity ofretinopathy in type 1 diabetes.
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Blood sphingolipidomics in healthy humans: impact of sample collection methodology.
Samar M. Hammad,Jason S. Pierce,Farzan Soodavar,Kent J. Smith,Mohammed M. Al Gadban,Barbara Rembiesa,Richard L. Klein,Richard L. Klein,Yusuf A. Hannun,Jacek Bielawski,Alicja Bielawska +10 more
TL;DR: HBPLC-MS/MS should provide a tool for clinical testing of circulating bioactive sphingolipids in human blood and determine levels of sphingoid bases and SM species in isolated lipoprotein classes.