Nanlan Luo

TL;DR: A new role is suggested for adiponectin as an autocrine factor in adipose tissues: promoting cell proliferation and differentiation from preadipocytes into adipocytes, augmenting programmed gene expression responsible for adipogenesis, and increasing lipid content and insulin responsiveness of the glucose transport system in adipocytes.

TL;DR: In this article, the authors examined the relationship between circulating levels of total adiponectin and the relative distribution of multimeric forms with key features of the metabolic syndrome and concluded that it is HMW quantity, not total or HMW-to-total adiponiectin ratio, that was primarily responsible for these relationships.

TL;DR: Observations suggest that oxLDL-mediated increase in ALBP gene expression accelerate cholesterol ester accumulation, and that this is an important component of the genetic program regulating conversion of macrophages to foam cells.

TL;DR: The results suggest that activation of both NF-kappaB and PKC signaling pathways is necessary for oxLDL-induced ALBP/aP2 gene expression in THP-1 macrophages and that the upregulation of the fatty acid carrier may be a necessary event in foam cell formation.

TL;DR: These studies provide new insights into potential mechanisms of adiponectin-mediated alterations in lipid metabolism and macrophage foam cell formation which may impact the development of atherosclerosis.