Showing papers by "Richard P. Wenzel published in 1973"

Transmission of Rhinovirus Colds by Self-Inoculation

Abstract: We investigated transmission of rhinovirus colds by examining shedding by infected patients, survival of virus outside the host, and inoculation of susceptible persons Two of 25 infected

Revised (1972-1973) Bivalent Influenza Vaccine: Serum and Nasal Antibody Responses to Parenteral Vaccination

Abstract: A new (1972-1973), more potent inactivated influenza vaccine was evaluated for acceptability and effectiveness in stimulating serum and nasal antibodies. The vaccine contained 700 chick cell agglutination (CCA) units of A2Hong Kong antigen and 300 CCA units of B antigen (B/Mass/71). Injection of the vaccine into 100 middle-aged and elderly volunteers was well tolerated and effective in stimulating serum hemagglutination inhibition (HI) and nasal neutralizing antibody to the A2component. All men with undetectable serum HI titers of A direct correlation between serum HI antibody titers and nasal neutralizing antibody titers was demonstrated. All men with ≥ 16-fold serum rise had ≥ 4-fold nasal antibody rises. Since both serum and nasal antibodies may have protective roles, influenza vaccines should induce high titers of both systemic and local antibodies.

Clinical applications of Australia/hepatitis-associated antigen

Abstract: The identification and characterization in recent years of the Australia or hepatitis-associated antigen represents an important breakthrough in our knowledge of the natural history of viral hepatitis. This report summarizes the present status of our knowledge of this antigen and the relationship to various clinical situations.