R
Richard R. Shivers
Researcher at University of Western Ontario
Publications - 62
Citations - 2735
Richard R. Shivers is an academic researcher from University of Western Ontario. The author has contributed to research in topics: Tight junction & Blood–brain barrier. The author has an hindex of 28, co-authored 62 publications receiving 2683 citations.
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Journal ArticleDOI
Astrocyte-mediated induction of tight junctions in brain capillary endothelium: an efficient in vitro model.
TL;DR: Results of this study clearly demonstrate the local control of tight junction biogenesis in brain capillary endothelial cells depends on: (1) an astrocyte-produced factor(s), and (2) a 'competent' (cell-produced) extracellular matrix.
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Structural pathways for macromolecular and cellular transport across the blood-brain barrier during inflammatory conditions. Review.
TL;DR: This review will present evidence that the previous studies by the authors and other researchers established a framework for subsequent transmission, scanning and high-voltage electron microscopic (HVEM) investigations concerning ultrastructural, ultracytochemical and immunoultra-structural alterations of the cerebral ECs and the mechanisms of the BBB transport that occurs after CNS injury.
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Primary culture of capillary endothelium from rat brain
Phillip D. Bowman,A. Lorris Betz,Diane Ar,Jerry S. Wolinsky,Jack B. Penney,Richard R. Shivers,Gary W. Goldstein +6 more
TL;DR: Primary cultures of brain capillary endothelial cells retained both endothelial and blood-brain barrier features and were joined together by tight junctions.
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Evidence that disruption of connexon particle arrangements in gap junction plaques is associated with inhibition of gap junctional communication by a glycyrrhetinic acid derivative.
Gary S. Goldberg,Alonso P. Moreno,John F. Bechberger,Stephen S. Hearn,Richard R. Shivers,Daniel J. MacPhee,Yu Chun Zhang,Christian C. Naus +7 more
TL;DR: Evidence is presented that while exposure to glycyrrhetinic acid derivatives may not affect protein synthesis or location, it does seem to alter connexon particle packing in gap junction plaques.
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Polymer blend latex films : morphology and transparency
TL;DR: In this paper, a transparent mixture of two types of particles in dispersion, one composed of a high-T g polymer [poly(methyl methacrylate), PMMA] ; the other a copolymer of butyl methacyl and butyl acrylate [P(BMA-co-BA] with T g ≤ 10 °C, were obtained under air-drying conditions.