Riëtte van Biljon

TL;DR: The transcriptional regulatory network of Pf AP2-G is defined by identifying its DNA binding sites genome-wide, which vary depending on the route of sexual conversion and rely on interactions with the PfAP2-I transcription factor.

TL;DR: Collectively, this data provides the most accurate, complete and comparative chromatin proteomic analyses of the entire life cycle development of malaria parasites and provides insights into the intricacies characterising Plasmodial developmental biology.

TL;DR: The gametocyte transcriptome serves as the blueprint for sexual differentiation and will be a rich resource for future functional studies on this critical stage of Plasmodium development, as the intraerythrocytic transcriptome has been for the authors' understanding of the asexual cycle.

TL;DR: Ester 7 was identified as the best candidate for further investigation as a potential drug in search for new, safe and effective antimalarial drugs and revealed that the targeted hybrids were all thermally more stable than DHA, which may be beneficial to the high temperature storage conditions that prevail in malaria endemic countries.

TL;DR: The gametocyte transcriptome serves as the blueprint for sexual differentiation at the mRNA transcript level and will be a rich resource for future functional studies on this critical stage of Plasmodium development, as the intraerythrocytic transcriptome has been for the authors' understanding of the 48-hour asexual cycle.